Role and Applications of Experimental Animal Models of Fontan Circulation
Zakaria Jalal,
Elise Langouet,
Nabil Dib
et al.
Abstract:Over the last four decades, the Fontan operation has been the treatment of choice for children born with complex congenital heart diseases and a single-ventricle physiology. However, therapeutic options remain limited and despite ongoing improvements in initial surgical repair, patients still experience a multiplicity of cardiovascular complications. The causes for cardiovascular failure are multifactorial and include systemic ventricular dysfunction, pulmonary vascular resistance, atrioventricular valve regur… Show more
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