Rol de los receptores de adenosina en la interacción adipocito-macrófago durante la obesidad

Meriño, Miguel; Briones, Lautaro; Palma, Verónica; Herlitz, Kurt; Escudero, Carlos

doi:10.1016/j.endinu.2017.03.010

Cited by 11 publications

(4 citation statements)

References 67 publications

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“…We generated the expression profile of the entire set of non-visual GPCRs by using a high-throughput RT-PCR Array GPCR panel in mouse adipose tissue and differentiating adipocytes and re-analyzing RNA sequencing data of adipose tissue from healthy and obese human subjects. Many of the GPCRs with striking expression profiles have been comprehensively characterized for their adipose-specific functions and have attracted considerable attention in the drug discovery field [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Chemokines and chemokine receptors have long been associated with obesitylinked inflammation, and insulin resistance and modulation of the chemokine/Chemokine receptor axis is considered a novel approach for the treatment of obesity and associated metabolic disorders [39,40].…”

Section: Discussionmentioning

confidence: 99%

“…Many GPCRs in this list have previously been studied for their role in adipose biology. These include alpha-and beta-adrenergic receptors [11][12][13][14][15][16], adenosine receptors [19], free fatty acid receptors [7,17,18], adhesion receptors [20,21], hydroxycarboxylic acid receptors [22,23], gastric inhibitory peptide [27][28][29], chemokine receptors [30,31] and many others [32][33][34][35]. Interestingly, many GPCRs with notable expression profiles in adipose tissue and adipocytes have no known role in adipose metabolism.…”

Section: Gpcrs Of Interestmentioning

confidence: 99%

“…βARs are also involved in thermogenesis in brown adipose tissue [15]. In addition to the βARs, several other GPCRs have been shown to play important functional roles in white and brown fat including alpha-adrenergic receptors [16], free fatty acid receptors [7,17,18], adenosine receptors [19], adhesion receptors [20,21], hydroxycarboxylic acid receptors [22,23], and many others [9]. These still represent a significantly small fraction of the total number of GPCRs, and the functional significance of a vast majority of GPCRs is not known in adipose metabolism.…”

Section: Introductionmentioning

confidence: 99%

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Profiling of G-Protein Coupled Receptors in Adipose Tissue and Differentiating Adipocytes Offers a Translational Resource for Obesity/Metabolic Research

Mahri

Okla

Rashid

et al. 2023

Cells

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G protein-coupled receptors (GPCRs) are expressed essentially on all cells, facilitating cellular responses to external stimuli, and are involved in nearly every biological process. Several members of this family play significant roles in the regulation of adipogenesis and adipose metabolism. However, the expression and functional significance of a vast number of GPCRs in adipose tissue are unknown. We used a high-throughput RT-PCR panel to determine the expression of the entire repertoire of non-sensory GPCRs in mouse white, and brown adipose tissue and assess changes in their expression during adipogenic differentiation of murine adipocyte cell line, 3T3-L1. In addition, the expression of GPCRs in subcutaneous adipose tissues from lean, obese, and diabetic human subjects and in adipocytes isolated from regular chow and high-fat fed mice were evaluated by re-analyzing RNA-sequencing data. We detected a total of 292 and 271 GPCRs in mouse white and brown adipose tissue, respectively. There is a significant overlap in the expression of GPCRs between the two adipose tissue depots, but several GPCRs are specifically expressed in one of the two tissue types. Adipogenic differentiation of 3T3-L1 cells had a profound impact on the expression of several GPCRs. RNA sequencing of subcutaneous adipose from healthy human subjects detected 255 GPCRs and obesity significantly changed the expression of several GPCRs in adipose tissue. High-fat diet had a significant impact on adipocyte GPCR expression that was similar to human obesity. Finally, we report several highly expressed GPCRs with no known role in adipose biology whose expression was significantly altered during adipogenic differentiation, and/or in the diseased human subjects. These GPCRs could play an important role in adipose metabolism and serve as a valuable translational resource for obesity and metabolic research.

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Section: Discussionmentioning

confidence: 99%

Section: Gpcrs Of Interestmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Profiling of G-Protein Coupled Receptors in Adipose Tissue and Differentiating Adipocytes Offers a Translational Resource for Obesity/Metabolic Research

Mahri

Okla

Rashid

et al. 2023

Cells

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“…Compounds designed to encapsulate therapeutics can have surface modifications that are recognized by receptors on macrophages. There are defining receptors such as F4/80, CD11b, and CD68 that are expressed on all macrophages [48–50], but subpopulations can additionally express others–such as those for mannose, lectin, adenosine [51], and folate [52]. Although not exclusively macrophage-specific, they allow targeting of cells of particular phenotypes and activation states.…”

Section: Macrophages As a Therapeutic Target In Metabolic Diseasementioning

confidence: 99%

Macrophage-Targeted Therapeutics for Metabolic Disease

Peterson

Cottam

Kennedy

et al. 2018

Trends in Pharmacological Sciences

101

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Macrophages are cells of the innate immune system that are resident in all tissues, including metabolic organs such as the liver and adipose tissue (AT). Because of their phenotypic flexibility, they play beneficial roles in tissue homeostasis, but they also contribute to the progression of metabolic disease. Thus, they are ideal therapeutic targets for diseases such as insulin resistance (IR), nonalcoholic fatty liver disease (NAFLD), and atherosclerosis. Recently, discoveries in the area of drug delivery have facilitated phenotype-specific targeting of macrophages. In this review we discuss advances in potential therapeutics for metabolic diseases via macrophage-specific delivery. We highlight micro- and nanoparticles, liposomes, and oligopeptide complexes, and how they can be used to alter macrophage phenotype for a more metabolically favorable tissue environment.

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