Roentgen Therapy in Cushing's Syndrome Without Adrenocortical Tumor*

Dohan, F. C.; Raventos, A.; Boucot, Nancy G.; Rose, Edward

doi:10.1210/jcem-17-1-8

Cited by 54 publications

(11 citation statements)

References 8 publications

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“…This has already been reported for about one-third of such patients treated by deep x-ray therapy (Dohan et al, 1957), and for several treated by surgery or 90Y implantation (Molinatti et al, 1967). Recent analysis (Fraser and Wright, 1968b) of our first 31 Cushing's disease patients followed for one year or more after 90Y implant, given in various doses as we discovered the optimal plan, has shown the practical importance of segregating those with obvious pituitary tumours, as they are much more prone to recur.…”

Section: Acromegalysupporting

confidence: 54%

Human pituitary disease.

Fraser¹

1970

BMJ

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Section: Acromegalysupporting

confidence: 54%

Human pituitary disease.

Fraser¹

1970

BMJ

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“…In the largest study with 338 patients and a 20-year follow-up period the 10-year progression-free survival for non-secreting adenomas was 97%, compared to 89% in secreting adenomas (significance of p < 0.005) [13] and in the study from McCord et al [64] a trend has been described with p = 0.079. Radiotherapy alone can reduce and control the prolactin levels in 44-79% [7,30,91,102], somatomedin-C and GH levels in 70-90% [38,55,70,71,84,102] and hypercortisolism in 50-100% [22,25,29,38,45,48,64,68,102]. Although there is a considerable delay before response is obtained, GH levels decrease to a rate of 10-30% per year and ACTH remissions were achieved 6-60 months after irradiation and in most cases during the first 2 years [38,55,70,71,82,84,102].…”

Section: Effect Of Treatmentmentioning

confidence: 99%

Radiation Therapy in the Multimodal Treatment Approach of Pituitary Adenoma

Becker¹,

Köcher

Kortmann³

et al. 2002

Strahlentherapie und Onkologie

140

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Conventional radiation therapy of pituitary adenoma is highly effective. It is recommended after subtotal resection of primary tumors such as macroadenomas, after gross total resection from endocrine active adenomas with postsurgical hormone secretion and for recurrent tumors. Radiosurgery seems to be a possible treatment alternative in experienced centers, and only in patients with adenomas smaller than 25-30 mm with a minimum distance of 2-3 mm to the chiasm.

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“…The postulate that the syndrome when associated with adrenal hyperplasia is the result of increased secretion of adrenocorticotropin (ACTH) satisfactorily explains the bilateral adrenal hyperplasia, the increased responsiveness of the adrenal glands to ACTH and the increased amounts of adrenal steroids found in the urine and blood (1). This postulate also is compatible with the fact that therapeutic success has been achieved in some cases following hypophysectomy (2) or x-ray irradiation of the pituitary gland (3). However, Paris et al (4) and Savers (5), after a careful review of the evidence, concluded that there is no demonstrable increase in blood levels of ACTH in cases of Cushing's syndrome associated with adrenal hyperplasia.…”

mentioning

confidence: 89%

A Possible Explanation for Cushing's Syndrome Associated With Adrenal Hyperplasia*

Nugent

Eik‐Nes

Kent

et al. 1960

The Journal of Clinical Endocrinology & Metabolism

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The postulate that Cushing's syndrome associated with bilateral adrenal hyperplasia results from an increased secretion of adrenocorticotropin (ACTH) satisfactory explains man}'' aspects of the disorder. However, the absence of a measurable increase in blood concentration of ACTH in such patients has led some investigators to assume that abnormal ACTH secretion does not account for the disorder. In the present investigation, constant intravenous infusions of small amounts of ACTH (1.5-5.0 i.u. per clay) were given for four-day periods to 7 normal young men at a rate calibrated so that they should not result in a measurable elevation of the blood ACTH level. In 4 of the 7 subjects, a fairly constant elevation of the plasma level of 17-hydroxycorticosteroids (17-OH-CS) developed during the four-day infusions. In 5 of the 7 subjects the response of the plasma 17-OH-CS level to maximal stimulation with ACTH, when tested two hours after ending the constant infusion, was increased above the control response. A relatively constant elevation of plasma 17-OH-CS concentration, with loss of the normal diurnal variation and increased responsiveness to ACTH, also characterized the plasma 17-OH-CS pattern in patients with Cushing's syndrome and adrenal hyperplasia. Thus, in view of the limits of sensitivity of present methods for the detection of ACTH in the blood, the absence of a measurable elevation of blood ACTH concentration is not a valid objection to the hypothesis that a constant secretion of ACTH is the basis for Cushing's syndrome associated with adrenal hyperplasia.

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Roentgen Therapy in Cushing's Syndrome Without Adrenocortical Tumor*

Cited by 54 publications

References 8 publications

Human pituitary disease.

Human pituitary disease.

Radiation Therapy in the Multimodal Treatment Approach of Pituitary Adenoma

A Possible Explanation for Cushing's Syndrome Associated With Adrenal Hyperplasia*

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