Rodenticide exposure in wood mouse and house mouse populations on farms and potential secondary risk to predators

Tosh, David G.; McDonald, Robbie A.; Bearhop, Stuart; Llewellyn, Neville; Montgomery, W. Ian; Shore, Richard F.

doi:10.1007/s10646-012-0886-3

Cited by 38 publications

(27 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These laboratory-inbred Formosan wood mice show enhanced exploratory behaviors that enable them to jump down from the platform of an elevated plus maze, which is up to 65 cm in height. These increased exploratory behaviors in laboratory-inbred Formosan wood mice are similar to the behaviors of mice living in the natural environment according to our subjective observations and other studies (Hauser et al, 2009;Kennedy and Elwood, 1988;Kuwahara et al, 2000;Lejeune et al, 2000;Perrigo et al, 1993;Rosalino et al, 2013;Takechi and Hayashi, 2012;Tosh et al, 2012). The differences in the behavioral responses of wood mice compared with those of common laboratory mice have been shown in previous studies (Hauser et al, 2009;Kennedy and Elwood, 1988;Kuwahara et al, 2000;Lejeune et al, 2000;Perrigo et al, 1993;Rosalino et al, 2013;Takechi and Hayashi, 2012;Tosh et al, 2012), and these observations and results provide further understanding of the behavioral responses and potential dominance of wood mice.…”

Section: Introductionsupporting

confidence: 88%

“…Recently, more studies on wood mice have been related to environmental pollution (Okano et al, 2016) and stress or behavioral responses in the wild (Malkemper et al, 2015;Monarca et al, 2015;Navarro-Castilla and Barja, 2019;Wan-Long and Zheng-Kun, 2016). Some studies have focused on comparisons of the physiological and behavioral responses between wood mice and common laboratory mice (Lejeune et al, 2000;Shieh et al, 2008;Shieh and Yang, 2018;Tosh et al, 2012). The Formosan wood mouse (A. semotus) is an endemic Taiwanese rodent, and most reports related to Formosan wood mice are field studies (Huang et al, 1997;Lee et al, 2001;Lin et al, 1993;Lin and Shiraishi, 1992a,b).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exploratory and agile behaviors with central dopaminergic activities in open field tests in Formosan wood mice (Apodemus semotus)

Shieh

Yang

2019

Journal of Experimental Biology

View full text Add to dashboard Cite

Taiwan is a mountainous island, and nearly 75% of its lands are 1000 m above sea level. Formosan wood mice, Apodemus semotus, are endemic rodents and are broadly distributed at altitudes between 1400 and 3700 m in Taiwan. Interestingly, Formosan wood mice show similar locomotor activity in the laboratory as they do in the wild. Hence, we are interested in studying whether exploratory behaviors and central dopaminergic activity are changed in the open field test. We used male C57BL/6J mice as the control, comparing their behavioral responses in the open field, step-down inhibitory avoidance discrimination and novel object recognition tests with those of male Formosan wood mice. We also examined dopamine and its major metabolite 3,4dihydroxyphenylacetic acid in the medial prefrontal cortex, striatum and nucleus accumbens. In open field tests, Formosan wood mice revealed higher levels of locomotion and exploration than C57BL/6J mice. Learning and memory performance in the novel object recognition test was similar in both Formosan wood mice and C57BL/6J mice, but more agile responses in the inhibitory avoidance discrimination task were found in Formosan wood mice. There was no difference in behavioral responses in the open field test between new second-generation Formosan wood mice and Formosan wood mice that were inbred for more than 10 generations. After repeated exposure to the open field test, high levels of locomotion and exploration as well as central dopaminergic activities were markedly persistent in Formosan wood mice, but these activities were significantly reduced in C57BL/6J mice. Diazepam (anxiolytic) treatment reduced the higher exploratory activity and central dopaminergic activities in Formosan wood mice, but this treatment had no effect in C57BL/6J mice. This study provides comparative findings, as two phylogenetically related species showed differences in behavioral responses.

show abstract

Section: Introductionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Exploratory and agile behaviors with central dopaminergic activities in open field tests in Formosan wood mice (Apodemus semotus)

Shieh

Yang

2019

Journal of Experimental Biology

View full text Add to dashboard Cite

show abstract

“…However, rodents can develop a resistance to anticoagulants (e.g., Myllymäki 1995;Salmon and Lawrence 2006), and anticoagulants can pose some risk to non-target scavengers and predators, although this risk is primarily attributed to second-generation anticoagulants (Stone et al 2003;Gabriel et al 2012;Tosh et al 2012). Zinc phosphide poses very little risk to non-target scavengers and predators (Eason et al 2010) but does have a high risk of toxicity to non-target species that might consume the bait directly (Marsh 1987).…”

mentioning

confidence: 99%

Cholecalciferol plus diphacinone baits for vole control: a novel approach to a historic problem

Baldwin

Meinerz

Witmer³

2015

J Pest Sci

View full text Add to dashboard Cite

Combination baits containing cholecalciferol plus an anticoagulant are effective against commensal rodents resistant to anticoagulants, and they likely pose less risk than anticoagulant-only rodenticides due to lower concentrations of active ingredients and shorter time to death. However, these combination baits have not been tested for agricultural rodent pests. Therefore, we established a study to test the efficacy of cholecalciferol plus diphacinone artichoke bract and pellet baits to determine their ability to manage California voles Microtus californicus in artichokes, where resistance to anticoagulants is known to occur. Field tests using radiocollared voles indicated that bract baits were highly efficacious (85 %), although pellet baits were less effective (60 %). Low observed efficacy of pellet baits may have resulted from poor weather following application during the second sampling period; further testing may yield more positive results. We observed a bimodal distribution in timing of death, with one group of voles dying between 4.3 and 5.8 days post-consumption; the other group died between 9.0 and 14.5 days post-consumption. Deaths in the first group were attributed to cholecalciferol, while deaths in the second group were likely due to chronic anticoagulant exposure. Almost double the proportion of voles that died from bract consumption did so during the early period when compared to their pellet plot counterparts. This suggests that voles were consuming greater quantities of bract baits over a shorter period of time when compared to the pellet bait. Collectively, these findings indicate that baiting with cholecalciferol plus diphacinone coated bracts is an effective method for controlling vole populations in artichokes. Key message• Cholecalciferol plus diphacinone could be an effective alternative to chlorophacinone for managing California vole populations but has not been field tested • Our findings indicate that cholecalciferol plus diphacinone bract baits were very effective at reducing vole populations in artichoke fields; pellet baits were less effective • Time to death is quicker with cholecalciferol plus anticoagulant baits than with anticoagulants alone, thereby reducing secondary poisoning hazards • This combination bait shows promise for use in field applications.

show abstract

“…Modifications to how rodenticides are applied are unlikely to be successful at reducing nontarget exposure if it is not understood how rodenticides travel from the point of application to nontarget species. Studies examining the initial stages of rodenticide transfer from known agricultural or commensal application sources have documented the widespread transfer of rodenticides into both target and nontarget species in the surrounding areas (Silberhorn et al 2003, Tosh et al 2012, Vyas et al 2013, Elliott et al 2014, Geduhn et al 2014). The bait in these studies was applied according to legal methods (except as noted in Tosh et al 2012), in many cases by the researchers themselves, yet the rodenticides were still detected in a wide range of nontarget taxa, from invertebrates to small mammals to passerines and raptors.…”

Section: Exposure Pathwaysmentioning

confidence: 99%

“…The original source(s) of the rodenticide are often unknown; the nearest known source may be distant, outside of the species' habitat, and/or the individual's home range (Berny 2007). The delayed toxicity of anticoagulant rodenticides and their persistence within tissues can result in contaminated rodents being found within and adjacent to the treated area weeks or months after bait application (Sage et al 2008, Tosh et al 2012, Geduhn et al 2014. After brodifacoum applications for island eradications of introduced rodent species, the long half-life of brodifacoum in tissues has resulted in it cycling through food webs in the ecosystems for months or years (Ebbert and Burek-Huntington 2010, Pitt et al 2015, Rueda et al 2016, Siers et al 2016.…”

Section: Exposure Pathwaysmentioning

confidence: 99%

What Do We Need to Know to Assess Individual and Population-level Effects on Wildlife from Anticoagulant Rodenticides?

Quinn¹,

Swift²

2018

vertebrate_pest_conference

View full text Add to dashboard Cite

Anticoagulant rodenticides have been detected in many species of wildlife worldwide; yet the origins, exposure pathways, and effects of this exposure are not well understood. Furthermore, to accurately characterize the risks from rodenticide use, information is needed on what proportion of populations are being exposed, what proportion of the exposed individuals are affected, and in what ways. The relationship between anticoagulant rodenticide concentrations found in wildlife and the rate of mortality or illness is the subject of much current research. Residue levels observed in liver and whole body analyses vary, and overlap extensively among apparently healthy asymptomatic individuals and sublethal and lethal cases. Results from laboratory studies also show there can be wide variability in lethal and sublethal effects among and within taxonomic groups. Correlating the sublethal and reproductive effects observed in laboratory studies with realistic exposure scenarios and effects in the wild is needed to improve risk assessments. For species with limited numbers/declining populations, a critical question is whether the rodenticide exposure documented in individual animals inhibit population growth or contribute to population declines by lowering survival and reproductive success. This information is essential to the regulatory agencies that must weigh the risks and benefits of rodenticide uses and identify restrictions that are effective in reducing risks to wildlife. A primary objective of this symposium was to facilitate communication between regulators and researchers. Current research on many of these topics was presented, and was followed by discussions on how to improve our understanding of what factors lead to wildlife exposure and improve our ability to assess the effects of exposure on individuals and populations. A collaborative approach will be developed to design studies that provide regulatory and wildlife management agencies with additional science on which to base their decisions.

show abstract

Rodenticide exposure in wood mouse and house mouse populations on farms and potential secondary risk to predators

Cited by 38 publications

References 32 publications

Exploratory and agile behaviors with central dopaminergic activities in open field tests in Formosan wood mice (Apodemus semotus)

Exploratory and agile behaviors with central dopaminergic activities in open field tests in Formosan wood mice (Apodemus semotus)

Cholecalciferol plus diphacinone baits for vole control: a novel approach to a historic problem

What Do We Need to Know to Assess Individual and Population-level Effects on Wildlife from Anticoagulant Rodenticides?

Contact Info

Product

Resources

About