Rodent Transplantation Medicine

Gong, Weihua

doi:10.1007/978-94-017-9472-5_1

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2020

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“…We believe that small animal models of NMP and subsequent transplantation may provide an important experimental system in order to overcome some of the limitations of large animal models, by facilitating the careful characterization and dissection of the molecular processes going on during NMP. Although kidney perfusion techniques and renal transplantation in rats and mice have been studied before, to our knowledge, a small animal model of machine perfusion and subsequent transplantation is yet to be reported 20‐24 …”

Section: Introductionmentioning

confidence: 99%

A protocol for rat kidney normothermic machine perfusion and subsequent transplantation

et al. 2020

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End‐stage renal disease is a major global health burden. The only definitive treatment existing is renal transplantation. Worldwide, the demand for donated kidneys by far exceeds the supply. A novel technique for organ preservation, normothermic machine perfusion (NMP), now promises to increase the potential pool of available organs by extending the spectrum of donors and reducing the incidence of graft failure. First studies in humans and large animals are being performed with promising results, but refinement of the technique, buffer, and machines involved is labor‐intensive and expensive. To our knowledge, this is the first report of a small animal model of NMP and subsequent transplantation.

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Section: Introductionmentioning

confidence: 99%