Rodent Models of Stress-Induced Depression: The Link Between Stress and Immune System Related Changes

McGuinness, B. W.; Harkin, Andrew

doi:10.1007/978-3-319-13602-8_3

Cited by 3 publications

(2 citation statements)

References 191 publications

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“…Monocyte and microglial activation may be reversed by administration of immunosuppressive drugs, including nonsteroidal antiinflammatories ( Muller, 2010 ; Khan et al, 2014 ), N-acetylcysteine ( Dean et al, 2011 ), and minocycline ( Levkovitz et al, 2010 ), although such treatments have not been systematically investigated in psychiatric disorders, with further potential for novel immunosuppressive interventions. Use of nonsteroidal antiinflammatories, N-acetylcysteine, minocycline, and novel immunomodulating drugs in animal models (reviewed by McGuinness and Harkin, 2015 ) could be examined for effectiveness in rectifying behavioral abnormalities. Models will enable in-depth studies on the molecular mechanism of immune mediated behavioral abnormalities and their correction by drug treatment.…”

Section: Grmentioning

confidence: 99%

Stress-Related Immune Markers in Depression: Implications for Treatment

Hughes¹,

Connor²,

Harkin

2016

IJNPPY

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Major depression is a serious psychiatric disorder; however, the precise biological basis of depression still remains elusive. A large body of evidence implicates a dysregulated endocrine and inflammatory response system in the pathogenesis of depression. Despite this, given the heterogeneity of depression, not all depressed patients exhibit dysregulation of the inflammatory and endocrine systems. Evidence suggests that inflammation is associated with depression in certain subgroups of patients and that those who have experienced stressful life events such as childhood trauma or bereavement may be at greater risk of developing depression. Consequently, prolonged exposure to stress is thought to be a key trigger for the onset of a depressive episode. This review assesses the relationship between stress and the immune system, with a particular interest in the mechanisms by which stress impacts immune function, and how altered immune functioning, in turn, may lead to a feed forward cascade of multiple systems dysregulation and the subsequent manifestation of depressive symptomology. The identification of stress-related immune markers and potential avenues for advances in therapeutic intervention is vital. Changes in specific biological markers may be used to characterize or differentiate depressive subtypes or specific symptoms and may predict treatment response, in turn facilitating a more effective, targeted, and fast-acting approach to treatment.

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Section: Grmentioning

confidence: 99%

Stress-Related Immune Markers in Depression: Implications for Treatment

Hughes¹,

Connor²,

Harkin

2016

IJNPPY

Self Cite

View full text Add to dashboard Cite

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“…In recent years, foreign psychology studies on depression have shown that depression is associated in the immune system (Mcguinness & Harkin, 2015). More recent studies suggest that depression is accompanied by immune activation, which is characterized by excessive secretion of cytokines, accompanied by acute phase reactions, increased peripheral blood mononuclear cells and neutrophil counts, and increased autoantibody titers.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐345‐5p regulates depression by targeting suppressor of cytokine signaling 1

Liu

Wang

et al. 2020

Brain and Behavior

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Resistant depression (TED) is the most common mental illness (Sowa-Kućma et al., 2018). About 350 million patients have become a serious public health problem all over the world (Cusin et al., 2017). Studies have shown that TED is also associated with other diseases, such as osteoporosis, diabetes, and cerebral ischemia (Grønli & Wynn, 2013; Nierenberg, Mcintyre, & Sachs, 2015). Even so, the researchers' understanding of depression is still very limited. In recent years, people have found the structural changes and functional impairment in some brain

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Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin

et al. 2023

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Pathophysiological mechanisms of major depression, which centre largely around adaptive changes in neuronal transmission and plasticity, neurogenesis, circuit and regional connectivity. The immune and endocrine systems are commonly implicated in driving these changes. An intricate interaction of stress hormones, innate immune cells and the actions of soluble mediators of immunity within the nervous system are described as associating with the symptoms of depression. Bridging endocrine and immune processes to neurotransmission and signalling within key cortical and limbic brain circuits is critical to understanding depression as a disorder of neuroimmune origins. Emergent areas of research include a growing recognition of the adaptive immune system, advances in neuroimaging techniques and mechanistic insights gained from transgenic animals. Elucidation of glial-neuronal interactions is providing additional avenues into promising areas of research, the development of clinically relevant disease models and the discovery of novel therapies. This narrative review focuses on molecular and cellular mechanisms that are influenced by inflammation and stress. The aim of this review is to provide an overview of our current understanding of depression as a disorder of neuroimmune origin, focusing on neuroendocrine and neuroimmune dysregulation in depression pathophysiology. Advances in current practice lie in pursuit of relevant biomarkers, as the potential of biomarker signatures to improve clinical outcomes is yet to be fully realised. Further investigations to expand biomarker panels including integration with neuroimaging, utilising individual symptoms to stratify patients into more homogenous subpopulations and targeting the immune system for new treatment approaches will help to address current unmet clinical need.

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Rodent Models of Stress-Induced Depression: The Link Between Stress and Immune System Related Changes

Cited by 3 publications

References 191 publications

Stress-Related Immune Markers in Depression: Implications for Treatment

Stress-Related Immune Markers in Depression: Implications for Treatment

MicroRNA‐345‐5p regulates depression by targeting suppressor of cytokine signaling 1

Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin

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