Rodent Models of Retinal Degeneration: From Purified Cells in Culture to Living Animals
Valérie Fradot,
Sébastien Augustin,
Valérie Fontaine
et al.
Abstract:Rodent models of retinal degeneration are essential for the development of therapeutic strategies. In addition to living animal models, we here also discuss models based on rodent cell cultures, such as purified retinal ganglion cells and retinal explants. These ex vivo models extend the possibilities for investigating pathological mechanisms and assessing the neuroprotective effect of pharmacological agents by eliminating questions on drug pharmacokinetics and bioavailability. The number of living rodent mode… Show more
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