Rodent Models for Assessing the Role of Stem Cells in Liver Development, Regeneration, and Carcinogenesis

Sanders, Jennifer; Hixson, Douglas C.

doi:10.1007/978-1-4614-7696-2_34

Cited by 1 publication

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“…Rodent studies have shown that successful engraftment and repopulation by transplanted hepatocytes require severe injury to the host liver to prevent host hepatocyte proliferation followed by a growth stimulus, such as 2/3 partial hepatectomy (Sanders and Hixson, ). This approach requires complicated models of liver injury in which the timing of transplantation is critical.…”

Section: Human Fetal Tissue Xenotransplant Models To Study the Mechanmentioning

confidence: 99%

Xenotransplantation Models to Study the Effects of Toxicants on Human Fetal Tissues

Spade

McDonnell

Heger

et al. 2014

Birth Defects Research Pt B

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Many diseases that manifest throughout the lifetime are influenced by factors affecting fetal development. Fetal exposure to xenobiotics, in particular, may influence the development of adult diseases. Established animal models provide systems for characterizing both developmental biology and developmental toxicology. However, animal model systems do not allow researchers to assess the mechanistic effects of toxicants on developing human tissue. Human fetal tissue xenotransplantation models have recently been implemented to provide human-relevant mechanistic data on the many tissue-level functions that may be affected by fetal exposure to toxicants. This review describes the development of human fetal tissue xenotransplant models for testis, prostate, lung, liver, and adipose tissue, aimed at studying the effects of xenobiotics on tissue development, including implications for testicular dysgenesis, prostate disease, lung disease, and metabolic syndrome. The mechanistic data obtained from these models can complement data from epidemiology, traditional animal models, and in vitro studies to quantify the risks of toxicant exposures during human development.

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Section: Human Fetal Tissue Xenotransplant Models To Study the Mechanmentioning

confidence: 99%

Xenotransplantation Models to Study the Effects of Toxicants on Human Fetal Tissues

Spade

McDonnell

Heger

et al. 2014

Birth Defects Research Pt B

Self Cite

View full text Add to dashboard Cite

show abstract

Rodent Models for Assessing the Role of Stem Cells in Liver Development, Regeneration, and Carcinogenesis

Cited by 1 publication

References 140 publications

Xenotransplantation Models to Study the Effects of Toxicants on Human Fetal Tissues

Xenotransplantation Models to Study the Effects of Toxicants on Human Fetal Tissues

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