Rodent Model of Parkinson’s Disease: Unilateral or Bilateral?

Zheng, Zhenlong; Poon, Wai Sang

doi:10.4172/2161-0460.1000319

J Alzheimers Dis Parkinsonism

2017

DOI: 10.4172/2161-0460.1000319

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Rodent Model of Parkinson’s Disease: Unilateral or Bilateral?

Zhenlong Zheng¹,

Wai Sang Poon²

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Cited by 3 publications

(2 citation statements)

References 66 publications

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“…Another important point is that independent of the site of injection, the 6-OHDA-induced dopamine depletion appears to be a valuable model to investigate clinical PD manifestations and gain more insight into the systemic abnormalities observed in this neurodegenerative disease (7)(8)(9)(10)19,20). Both the unilateral and bilateral 6-OHDA models have their advantages and disadvantages (20,21). However, none of the currently available animal models can completely reproduce the clinical characteristics of PD (21), although the unilateral 6-OHDA model used in the present study remains the most widely used model for experimental studies of PD in rats (22,23).…”

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“…Both the unilateral and bilateral 6-OHDA models have their advantages and disadvantages (20,21). However, none of the currently available animal models can completely reproduce the clinical characteristics of PD (21), although the unilateral 6-OHDA model used in the present study remains the most widely used model for experimental studies of PD in rats (22,23). Importantly, the immunohistochemical and cardiovascular data demonstrated here are consistent with previous studies of Parkinsonism in the unilateral 6-OHDA animal model of PD, suggesting that the rats were adequately lesioned (7,8,10,19,22).…”

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Sudden death in a rat model of Parkinson's disease

Scorza¹,

Rodrigues²,

Oliveira³

et al. 2021

Clinics

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confidence: 99%

mentioning

confidence: 99%

Sudden death in a rat model of Parkinson's disease

Scorza¹,

Rodrigues²,

Oliveira³

et al. 2021

Clinics

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Lateralisation in Parkinson disease

Riederer

Jellinger²,

Kolber

et al. 2018

Cell Tissue Res

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Asymmetry of dopaminergic neurodegeneration and subsequent lateralisation of motor symptoms are distinctive features of Parkinson's disease compared to other forms of neurodegenerative or symptomatic parkinsonism. Even 200 years after the first description of the disease, the underlying causes for this striking clinicopathological feature are not yet fully understood. There is increasing evidence that lateralisation of disease is due to a complex interplay of hereditary and environmental factors that are reflected not only in the concept of dominant hemispheres and handedness but also in specific susceptibilities of neuronal subpopulations within the substantia nigra. As a consequence, not only the obvious lateralisation of motor symptoms occurs but also patterns of associated non-motor signs are defined, which include cognitive functions, sleep behaviour or olfaction. Better understanding of the mechanisms contributing to lateralisation of neurodegeneration and the resulting patterns of clinical phenotypes based on bilateral post-mortem brain analyses and clinical studies focusing on right/left hemispheric symptom origin will help to develop more targeted therapeutic approaches, taking into account subtypes of PD as a heterogeneous disorder.

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Neurotoxic Mechanism and Shortcomings of MPTP, 6-OHDA, Rotenone and Paraquat-induced Parkinson’s Disease Animal Models

Okyere

Chao-rong

Dong

et al. 2021

VAT

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: Parkinson’s disease (PD) has caused most economy to lose their active human capital. Due to poor understanding of the pathophysiology of PD, PD animal models were developed to aid with the investigation of PD pathogenesis and therapy. Currently, the toxin induced and the genetic animal models are being used for most PD research. Most neurotoxin animal model’s studies on PD are focused on the motor features and economic importance associated with dopamine depletion; however, the molecular pathways for cell loss by these models and its usefulness in PD drug development have not been reported fully. In this review, we provided a summary of the toxic mechanism and shortcomings of four neurotoxins (6-OHDA, MPTP, Rotenone and, Paraquat) that are frequently used to mimic PD in animal models. This review will give readers basic knowledge on the best toxin to select for a specific PD experiment and also provide information that will help in development of future toxins with fewer shortcomings. This review also summarizes the mechanism and features of some PD genetic models.

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Rodent Model of Parkinson’s Disease: Unilateral or Bilateral?

Cited by 3 publications

References 66 publications

Sudden death in a rat model of Parkinson's disease

Sudden death in a rat model of Parkinson's disease

Lateralisation in Parkinson disease

Neurotoxic Mechanism and Shortcomings of MPTP, 6-OHDA, Rotenone and Paraquat-induced Parkinson’s Disease Animal Models

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