Rocking Promotes Sleep in Mice through Rhythmic Stimulation of the Vestibular System

Kompotis, Konstantinos; Hubbard, Jeffrey; Emmenegger, Yann; Perrault, Aurore A.; Mühlethaler, Michel; Schwartz, Sophie; Bayer, Laurence; Franken, Paul

doi:10.1016/j.cub.2018.12.007

Cited by 66 publications

(103 citation statements)

References 50 publications

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“…Local field potentials in the female fly brain were previously shown to differ between daytime and nighttime sleep (van Alphen et al, 2013) suggesting qualitative differences between them, with daytime sleep deemed to be lighter. Our studies are consistent with previous studies that showed that rocking can induce sleep in humans and mice (Perrault et al, 2019; Kompotis et al, 2019; Bayer et al, 2011). Orbital motion induced quiescence is completely reversible by pharmacological and behavioural interventions (Figure 3) and thus qualifies this criterion for sleep.…”

Section: Discussionsupporting

confidence: 93%

“…Based on previous studies of mammals including humans where rocking motion was found to induce daytime sleep (Kompotis et al, 2019; Perrault et al, 2019; Bayer et al, 2011) we set out to examine the effect of sustained orbital motion on flies. Here we report for the first time that gentle orbital motion (Figure 1a) induces sleep in D. melanogaster .…”

Section: Resultsmentioning

confidence: 99%

“…Increase in slow oscillations associated with consolidated sleep and memory formation was also reported by the study (Perrault et al, 2019). Similarly, the stimulation of vestibular and proprioceptive sensory inputs of mice were also seen to elicit a sustained boosting of slow-wave oscillations and increased density of sleep spindles, both of which are indicators of deep sleep (Kompotis et al, 2019; Bayer et al, 2011). The authors hypothesized that rocking mediated sensory inputs may directly or indirectly impact sleep centers in the brain, however, the underlying neuronal mechanisms remain elusive.…”

Section: Introductionmentioning

confidence: 93%

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Mechanosensory stimulation viaNanchungexpressing neurons can induce daytime sleep inDrosophila

Lone

Potdar

Venkataraman

et al. 2019

Preprint

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1The neurogenetic bases of sleep, a phenomenon considered crucial for well-being of organisms has 3 2 recently been under investigation using the model organism Drosophila melanogaster. Although 3sleep is a state where sensory threshold for arousal is enhanced, it is known that certain kinds of 3 4repetitive sensory stimuli such as rocking, can in fact promote sleep in humans. Here we report that 3 5 orbital motion aided mechanosensory stimulation promotes sleep in Drosophila, independent of the 3 6 circadian clock, but controlled by the homeostatic system. Mechanosensory receptor nanchung (Nan) 3 7 expressing neurons in the chordotonal organs mediate this sleep induction -flies where these neurons 3 8 are either silenced or ablated display significantly reduced sleep induction upon mechanosensory 3 9 stimulation. Transient activation of the Nan-expressing neurons also enhances sleep levels 4 0 confirming the role of these neurons in sleep induction. Thus, we show for the first time that 4 1 mechanosensory stimulation promotes sleep even in flies D. melanogaster and that it is mediated by 4 2 proprioceptors. 4 3

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Section: Discussionsupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Mechanosensory stimulation viaNanchungexpressing neurons can induce daytime sleep inDrosophila

Lone

Potdar

Venkataraman

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…Compared to the wide range of vibration frequency used in our studies, human and mouse studies investigating the effects of rocking on adult sleep used a narrow range of frequencies (0.16 -1.5 Hz) (Bayer et al, 2011;Kompotis et al, 2019;Perrault et al, 2019). Nevertheless, they found variable results in terms of the specific sleep parameters that were affected (e.g., sleep duration and sleep latency).…”

Section: Discussionmentioning

confidence: 92%

“…Anecdotal observations suggest that babies sleep better when gently rocked or bounced and people tend to fall asleep during long car rides. Several experimental studies have confirmed that rocking promotes sleep in infants, adult humans, and mice (Bayer et al, 2011;Kompotis et al, 2019;Korner et al, 1978;Perrault et al, 2019). Yet the underlying mechanisms are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Sleep Induction by Mechanosensory Stimulation inDrosophila

Öztürk-Çolak

McClanahan

Buchler

et al. 2020

Preprint

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2 Summary People tend to fall asleep when gently rocked or vibrated. Experimental studies have shown rocking promotes sleep in humans and mice. The prevailing "synchronization" model proposes synchronization of brain activity to mechanosensory stimuli mediates the phenomenon. The alternative "habituation" model proposes habituation, a form of non-associative learning, mediates sleep induction by monotonous stimulation. Here we show that gentle vibration promotes sleep in Drosophila in part through habituation. Vibration-induced sleep (VIS) leads to the accrual of homeostatic sleep credit, is associated with reduced arousability, and can be suppressed by heightened arousal. Sleep induction improves over successive blocks of vibration and exhibits stimulus specificity, supporting the habituation model. Multiple mechanosensory organs mediate VIS, and the magnitude of sleep gain depends on the vibration frequency and genetic background. Our findings suggest habituation is a major contributor to VIS, but synchronization of brain activity may play a role under certain stimulus conditions.

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Real‐Time Functional Assay of Volumetric Muscle Loss Injured Mouse Masseter Muscles via Nanomembrane Electronics

et al. 2021

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Skeletal muscle has a remarkable regeneration capacity to recover its structure and function after injury, except for the traumatic loss of critical muscle volume, called volumetric muscle loss (VML). Although many extremity VML models have been conducted, craniofacial VML has not been well-studied due to unavailable in vivo assay tools. Here, this paper reports a wireless, noninvasive nanomembrane system that integrates skin-wearable printed sensors and electronics for real-time, continuous monitoring of VML on craniofacial muscles. The craniofacial VML model, using biopsy punch-induced masseter muscle injury, shows impaired muscle regeneration. To measure the electrophysiology of small and round masseter muscles of active mice during mastication, a wearable nanomembrane system with stretchable graphene sensors that can be laminated to the skin over target muscles is utilized. The noninvasive system provides highly sensitive electromyogram detection on masseter muscles with or without VML injury. Furthermore, it is demonstrated that the wireless sensor can monitor the recovery after transplantation surgery for craniofacial VML. Overall, the presented study shows the enormous potential of the masseter muscle VML injury model and wearable assay tool for the mechanism study and the therapeutic development of craniofacial VML.

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Rocking Promotes Sleep in Mice through Rhythmic Stimulation of the Vestibular System

Cited by 66 publications

References 50 publications

Mechanosensory stimulation viaNanchungexpressing neurons can induce daytime sleep inDrosophila

Mechanosensory stimulation viaNanchungexpressing neurons can induce daytime sleep inDrosophila

Sleep Induction by Mechanosensory Stimulation inDrosophila

Real‐Time Functional Assay of Volumetric Muscle Loss Injured Mouse Masseter Muscles via Nanomembrane Electronics

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