Rocket “Eruca sativa”: A salad herb with potential gastric antiulcer activity

Alqasoumi, Saleh I.; Al-Sohaibani, Mohammed; Al‐Howiriny, Tawfeq A.; Al-Yahya, Mohammed A.; Rafatullah, Syed

doi:10.3748/wjg.15.1958

Cited by 103 publications

(84 citation statements)

References 43 publications

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“…The prevalence of this disease can lead to occur more often due to excessive drinking of alcohol, smoking, stress, infections, nutritional deficiency, abrupt use of nonsteroidal drugs for managing anti‐inflammatory diseases (NSAIDs); it is a multietiologic chronic disease (Alqasoumi, Al‐Sohaibani, Al‐Howiriny, Al‐Yahya, & Rafatullah, 2009; Gisbert, 2005; Süleyman et al., 2009). Pathologically, digestive ulcers located in the gastric and duodenal mucosa induce acute erosive and surface desquamatious ulcerative lesions following exposure to gastric juices, including gastric acid and pepsin (Alqasoumi et al., 2009; Huh et al., 2003). Disorders or decreases in gastric mucosa antioxidant defense systems have been implicated in the pathogenesis and progression of various gastric ulcers (Kwiecień, Brzozowski, Konturek, & Konturek, 2002).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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This study was designed to observe the possible protective effects of a triple‐fermented barley (Hordeum vulgare L.) extract (FBe) obtained by saccharification and using Saccharomyces cerevisiae and Weissella cibaria in alleviating gastric damage induced by a hydrochloric acid (HCl) and ethanol (EtOH) mixture in mice. After oral administration of FBe (300, 200, and 100 mg/kg) followed by 1 hr before and after the single treatment of HCl/EtOH (H/E) mixture, the hemorrhagic lesion scores, histopathology of the stomach, gastric nitrate/nitrite content, lipid peroxidation, and antioxidant defense systems including catalase and superoxide dismutase activities were observed. Following a single oral treatment of H/E‐induced gastric damages as measured by hemorrhagic gross lesions and histopathological gastric, ulcerative lesions were significantly and dose‐dependently (p < 0.01 or p < 0.05) inhibited in mice, when all three different doses of FBe were administered as compared to those in H/E control mice. In particular, FBe also increased gastric nitrate/nitrite content and strengthened the antioxidant defense, with a decrease in the level of gastric lipid peroxidation, but increased the activities of CAT and SOD. Moreover, the effects of FBe are comparable to that of ranitidine, a reference drug. The obtained results suggest that this fermented barley extract prevented mice from H/E‐induced gastric mucosal damages through the suppression of inflammatory responses and oxidative stress‐responsive free radicals. Thus, FBe can be useful to treat patients suffering from gastric mucosal disorders as a potent food supplement, and thereby, it would increase the necessity of application in the food industry.

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Section: Introductionmentioning

confidence: 99%

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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“…of glucosides, mineral salts and vitamin C and is therefore considered to be an excellent stomachic stimulant (Alqasoumi et al 2009, Katsarou et al 2016. E. sativa seed oil has antioxidant and antimicrobial properties (Khoobchandani et al 2010) and serves to inhibit the proliferation of tumour growth (Azarenko et al 2014).…”

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confidence: 99%

Effects of salt stress on water status, photosynthesis and chlorophyll fluorescence of rocket

Hniličková¹,

Hnilička²,

Martinková³

et al. 2017

Plant Soil Environ.

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Salinity is one of the significant factors affecting the productivity of plants. Considerable attention is paid to the study of salt stress effects on the physiological symptoms in various types of plants (Munns and Gilliham 2015, Negrão et al. 2017). High salt concentrations decrease the osmotic potential of soil, which decreases the availability of water and disrupts the transport of water and nutrients to plant roots (Munns 2002, Tester andDavenport 2003). Salinity causes both water stress and osmotic stress in plants and the accumulated salt ions have a toxic effect on plants. Water deficit causes a leaf turgor decrease, further causing stomata closure and decreases of stomatal conductance (g s ); one of the factors limiting photosynthesis rates (Chaves et al. 2009). There is also an ion imbalance due to the excessive collection of Na + and Cl -along with decreased absorption of other ions such as K + , Ca 2+ and Mn 2+ (Flowers and Colmer 2008).Photosynthesis is the most significant physiological process and, in all its phases, is affected by stress factors. Ashraf and Harris (2013) state that the mechanism of photosynthesis involves various components, including photosynthetic pigments and photosystems, the electron transport system, and CO 2 reduction pathways. Any damage at any level caused by a stress factor may reduce the overall photosynthetic capacity of a green plant.Rocket, commonly also known as arugula, roquette and rucola (Eruca sativa (L.) Mill.), is an annual species belonging to the mustard family (Brassicaceae), traditionally grown in the Mediterranean region. Thanks to its excellent nutritional properties, it is increasingly becoming important for its content Salinity is a significant environmental factor affecting physiological processes in plants. This study monitors the effect of salt stress induced by the NaCl solution (0 -deionized water; 50, 100, 200, 300 mmol/L) in rocket (Eruca sativa (L.) Mill.) cv. Astro over the course of 50 days. Salt stress significantly affected the monitored parameters. The osmotic potential decreased with increasing NaCl concentrations, while relative water content decrease did not take place until 200 mmol/L NaCl. Compared to the control group, transpiration (E) decreased at the concentration of 50 mmol/L NaCl and stomatal conductance (g s ) and net photosynthetic rate (P n ) decreased at 100 mmol/L NaCl. Further increase of salt concentrations did not affect P n and no significant differences g s , E and substomatal concentration CO 2 were measured between the concentrations of 200 and 300 mmol/L NaCl. A decrease of F v /F m took place from the concentration of 100 mmol/L NaCl, while differences between 200 and 300 mmol/L NaCl were also not significant. The obtained results therefore prove the tolerance of the E. sativa cv. Astro to salt stress. Effects of salt stress on water status, photosynthesis and chlorophyll fluorescence of rocket

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“…Moreov er, Alq asoumi (2010) reported that Er uca s ativ a extract protec t the liver against CCl4-i nduc ed hep atic inj ur y through its pot ent anti oxidant a ctivit y i n rats . Histopat hological st udies ( Alqasoumi et al , 2009) et al, 2009). It has been rep orted that t he r ocket seed poss ess es pot ent antioxidant and r enal prot ectiv e char act eristics ( Mahran et al, 1991;Yaniv et al, 1998;S arwar et al , 2007;Alqas oumi et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Effects of Eruca sativa seed oil on the histology of liver and kidney in rats

AlQudah¹

2017

Egypt. J. Exp. Biol. (Zoo.)

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Effects of Eruca sativ a se ed oil on t he histol ogy of liv er and kidney in rats ABSTRACT:The objectiv e of this s tud y was to i nvestigat e the possible ameli orativ e ef fect of Eruc a sativ a s eed oil on the hist opat hol ogical struct ure of t he liv er and kidneys of mal e albino rat s. A t ot al of f ourteen r ats wer e grouped i nt o two groups of 7 rats eac h. Gr oup 1 r ats s erved as c ontrol, whil e group 2 receiv ed 2 ml/kg B .W . of Eruc a sativ a s eed oil, dail y f or f our weeks thr oug h t he or al rout e (i.g.). A significant d ecreas e ( P < 0.05) in the absolute liver w eights w as observ ed in the treated group as c ompared with the c ontrol (9.66 ± 0. 55 and 10. 00 ± 2.07, respectiv el y). Also, the abs olute kidney w eights w ere f ound significantl y decreased ( P < 0.05) aft er treatment as compar ed t o c ontr ols ( 1.70 ± 0. 09 and 2.16 ± 0. 46, resp ectivel y). In the control group, the relative liv er index (%) w as 3. 86 grams and the r elativ e kidney index (%) was 0.83 g rams. In the exp erimental group, the relative i ndexes w ere 4. 05 grams and 0. 71 grams , f or liver and kidney, resp ectiv ely. Light micr oscopic examination of indicated some histop at hol ogical chang es i n bot h studied organs . In liv er, c ong estion i n the blood v ess els and sinus oid wer e observ ed. Moreover, the obvi ous chang e in t he kidneys was conges tion. In c oncl usion, t his st ud y show s t hat dail y administr ation of Eruc a sativ a s eed oil at a dose 2 ml/kg B .W ., f or 4 week s, c ould pat hologicall y aff ect som e vit al inter nal organs , such as liver and kidneys causing alt erati ons in t heir histol ogical struct ure. S o, it is r ecomm end ed t o be us ed at low sui table d ose. KEY WORDS:Eruc a sativ a oil, R ock et, Liver, Kidney, Rats , Histolog y, Light microsc ope CORRESP ONDENCE:Maisa Mohamm ad Amin Al -Q udah Department of Medical Lab orat or y S ciences , Facul t y of Scienc e, Al -Balqa Applied Universit y, Al -S alt 19117, J ordan .

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Rocket “Eruca sativa”: A salad herb with potential gastric antiulcer activity

Abstract: Rocket extract possesses anti-secretory, cytoprotective, and anti-ulcer activities against experimentally-induced gastric lesions. The anti-ulcer effect is possibly through prostaglandin-mediated activity and/or through its anti-secretory and antioxidant properties.

Cited by 103 publications

References 43 publications

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Effects of salt stress on water status, photosynthesis and chlorophyll fluorescence of rocket

Effects of Eruca sativa seed oil on the histology of liver and kidney in rats

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