Abstract:Abstracts:
Among the complex mechanisms of AF pathogenesis, intracellular calcium overload and
oxidative stress play a major role, both triggered by inflammatory processes. The additional basic
event taking place in AF is atrial fibrotic remodeling, again triggered by oxidative stress, which is
determined by connexins rearrangement and differentiation of fibroblasts into active collagensecreting
myofibroblasts. RhoA/ROCK system is the final pathway of a wide spectrum of molecular
effectors such as Angiotensin … Show more
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