2015
DOI: 10.1080/03610926.2013.815205
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Robustness of the shrinkage estimator for the relative potency in the combination of multivariate bioassays

Abstract: This paper investigates the robustness of the shrinkage Bayesian estimator for the relative potency parameter in the combinations of multivariate bioassays proposed in Chen et al.(1999), which incorporated prior information on the model parameters based on Jeffreys' rules. This investigation is carried out for the families of t-distribution and Cauchy-distribution based on the characteristics of bioassay theory since the t-distribution approaches the normal distribution which is the most commonly used distribu… Show more

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