Robustness in angiogenesis: Notch and BMP shaping waves

Beets, Karen; Huylebroeck, Danny; Moya, Iván M.; Umans, Lieve; Zwijsen, An

doi:10.1016/j.tig.2012.11.008

Cited by 66 publications

(58 citation statements)

References 98 publications

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“…In the case of endothelial lineage, this type of interaction results in the establishment of the sharp tip and stalk cell boundaries (reviewed in [49]). …”

Section: Tgfβ/bmpmentioning

confidence: 99%

Notch Signaling in Cell–Cell Communication Pathways

Bigas

Espinosa

2016

Curr Stem Cell Rep

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The Notch signaling pathway is a well-conserved molecular mechanism that serves the purpose of coordinating cellular events occurring within a group of neighboring cells. The interplay between ligands and receptors of the Notch family is crucial in determining Notch status and the outcome of any specific cellular event often triggered by other signaling pathways. However, different characteristics of the cells involved can also determine their capacity to send or receive specific signals. We have revised how Notch integrates some of the instructive signaling pathways to govern cell fate. Understanding how cells communicate and whether Notch positively or negatively regulates this process is critical for better understanding the mechanisms of cell and tissue homeostasis, which is relevant for regenerative medicine.

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“…In the case of endothelial lineage, this type of interaction results in the establishment of the sharp tip and stalk cell boundaries (reviewed in [49]). …”

Section: Tgfβ/bmpmentioning

confidence: 99%

Notch Signaling in Cell–Cell Communication Pathways

Bigas

Espinosa

2016

Curr Stem Cell Rep

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“…Angiogenesis is the formation of new blood vessels from preexisting vessels either by sprouting (sprouting angiogenesis) or splitting (intussusceptions) [1]. This growth of new capillary blood vessels is needed mainly for embryonic development but also contributes to organ growth after birth.…”

Section: Introductionmentioning

confidence: 99%

N-Hydroxy-6-(5-Nitro-Naphtalimide)-Hexanamide Inhibits Lysine Deacetylation, Mitigates Angiogenesis and Reduces Tumor Growth

Shankar

Sulka²,

Hubert

et al. 2015

J Cancer Sci

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In this report, we present a novel histone deacetylase inhibitor (HDACi) (N-Hydroxy-6-(5-nitro-naphtalimide)-hexanamide: ES8) that efficiently inhibits angiogenesis in relevant ex vivo models (Human umbilical vein endothelial cells (HUVEC), 3D aortic ring assay) and in vivo (chick chorioallantoic membrane (CAM), Zebrafish). Transcriptomic profiling reveals a set of ES8 specific genes that are not affected by the prototypical HDACi suberoylanilide hydroxamic acid (SAHA). Finally, ES8 also reduced tumor growth in mouse models of small cell lung cancer. Availability of a novel compound not centered exclusively on inhibition of angiogenic factors and inducing a characteristic transcription profile may be of interest to overcome resistance to currently used chemotherapies.Citation: Shiva Shankar TV, Sulka B, Hubert P, Hubaux R, Delvenne P, et al. N-Hydroxy-6-(5-Nitro-Naphtalimide)-Hexanamide Inhibits Lysine Deacetylation, Mitigates Angiogenesis and Reduces Tumor Growth. J Cancer Sci. 2015;2(1): 11.J Cancer Sci 2(1): 11 (2015) Page -02 ISSN: 2377-9292 HDACi that potently inhibits angiogenesis and that induces a unique transcriptional profile not shared by two other reference inhibitors.

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“…These decisions rely on the selective and coordinated microenvironment‐dependent activation of a number of signaling cascades, such as the Notch, Hedgehog, vascular endothelial growth factor (VEGF), and transforming growth factor beta (TGFβ) pathways 1. During embryonic development, formation of blood vessel networks relies on two processes: vasculogenesis, the de novo formation of blood vessels from differentiation of mesodermal precursor cells, and angiogenesis, the expansion of a pre‐existing vascular network through sprouting or splitting of vessels 2. The arterial and venous identities are determined by the mutual ligands/receptors ephrin B2 and EphB4, respectively, which regulate repulsion and segregation of endothelial cells 3.…”

mentioning

confidence: 99%

“…BMP mediates activation of ALK (Activin receptor‐like kinase, an endothelial‐specific member of the TGF‐β/BMP receptor family) and the subsequent phosphorylation of SMADs. The cross‐talk between the Notch and TGF‐β/BMP pathways occurs at the level of SMADs that form a complex with NICD in the nucleus and potentiate HES/HEY gene expression 2. The outcome of Notch signaling highly depends on the particular cellular context, including the presence of extracellular proteins in the microenvironment at certain concentrations.…”

mentioning

confidence: 99%

“…Cross‐talk occurs at the level of coactivator BMP ‐ SMAD s which are recruited to NICD bound to the Notch target gene DNA ‐binding protein CSL (also known as Recombination signal‐Binding Protein for immunoglobin‐κ J region, RBPJ κ). This in turn leads to activation of Notch target genes such as HES and HEY 1/2, and importantly also to the expression of the arterial marker ephrin B2 (reviewed in 2). BMPER (and TWSG 1) increase the expression of major BMP and Notch signaling targets (indicated by the thick red transcription indicators).…”

mentioning

confidence: 99%

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Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling

Osmanagic‐Myers

Rezniczek

2018

The FEBS Journal

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Two extracellular BMP modulators, BMPER and TWSG1, act in a pro‐BMP fashion to activate endothelial‐specific members of the TGF‐β/BMP receptor family. Through cross‐talk with the Notch signaling pathways, they are key regulators of downstream Notch targets, including ephrin B2. This adds to our understanding of BMP and Notch signaling, how these pathways converge, and thereby control arteriovenous specification.

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Robustness in angiogenesis: Notch and BMP shaping waves

Cited by 66 publications

References 98 publications

Notch Signaling in Cell–Cell Communication Pathways

Notch Signaling in Cell–Cell Communication Pathways

N-Hydroxy-6-(5-Nitro-Naphtalimide)-Hexanamide Inhibits Lysine Deacetylation, Mitigates Angiogenesis and Reduces Tumor Growth

Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling

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