A T-S model-dependent robust asynchronous fuzzy predictive fault-tolerant tracking control scheme is developed for nonlinear multiphase batch processes with time-varying tracking trajectories and actuator faults. Firstly, considering the influence of the mismatch between the previous phase state and the current phase controller during the switching, a T-S fuzzy switching model including the match and mismatch case is established. Depending on the fuzzy switching model, a robust fuzzy predictive fault-tolerant tracking controller is designed by considering the situation whether the model rules correspond to the controller rules. Secondly, using the related theories and methods, the system stability conditions presented by the linear matrix inequality considering the above conditions are provided to guarantee the stability of the system. By solving these stability conditions, the T-S fuzzy control law gain of each phase, the minimum running time of each match case and the maximum running time of each mismatch case are obtained. Then, through the maximum running time, the strategy of the switching signal in advance is adopted to avoid the occurrence of asynchronous switching, so as to ensure that the system can operate stably. Finally, the simulation results verify that the designed controller is effective and feasible.