“…Due to the dynamic, non-linear nature of the parkinsonian neuromuscular system, identified models or controller parameters which were initially suitable during controller tuning may become unsuitable or provide suboptimal performance during different tasks, times throughout the day or as the disease progresses. Advanced adaptive techniques which automatically update autoregressive model coefficients or controller gains may be required to overcome this limitation (Cameron and Seborg, 1984;Santaniello et al, 2011;Chaillet et al, 2017). Nevertheless, the PI parameter rule-tuning approach presented in this study provides improved performance over currently tested closed-loop controllers, is simple to implement in a clinical setting and adheres to clinical considerations.…”