Robust, routine haematology reference ranges for healthy adults

Wakeman, Lisa; Al‐Ismail, Saad; Benton, Ann; Beddall, A. J.; Gibbs, A.; Hartnell, Sally; Morris, Kirk; Munro, Roger

doi:10.1111/j.1365-2257.2006.00883.x

Cited by 61 publications

(52 citation statements)

References 6 publications

(5 reference statements)

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“…The decreased metabolic demand in females, decreased muscle mass, and lower iron stores due to menstruation are factors well known to contribute to lower hemoglobin in females compared with males. This is in line with studies that showed low serum ferritin in healthy asymptomatic menopausal females (16,17 ). The WHO hemoglobin cutoff for mild anemia is 11.1-11.9 g/dL in nonpregnant adult females and 11.1-12.9 g/dL in adult males (18 -20 ) and agrees well with the lower limits generated in this study.…”

Section: Discussionsupporting

confidence: 93%

Complex Biological Profile of Hematologic Markers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

et al. 2015

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BACKGROUND In a collaboration between the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) and the Canadian Health Measures Survey (CHMS), we determined reference value distributions using an a priori approach and created a comprehensive database of age- and sex-stratified reference intervals for clinically relevant hematologic parameters in a large household population of children and adults. METHODS The CHMS collected data and blood samples from 11 999 respondents aged 3–79 years. Hematology markers were measured with either the Beckman Coulter HmX or Siemens Sysmex CA-500 Series analyzers. After applying exclusion criteria and removing outliers, we determined statistically relevant age and sex partitions and calculated reference intervals, including 90% CIs, according to CSLI C28-A3 guidelines. RESULTS Hematology marker values showed dynamic changes from childhood into adulthood as well as between sexes, necessitating distinct partitions throughout life. Most age partitions were necessary during childhood, reflecting the hematologic changes that occur during growth and development. Hemoglobin, red blood cell count, hematocrit, and indices (mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration) increased with age, but females had lower hemoglobin and hematocrit starting at puberty. Platelet count gradually decreased with age and required multiple sex partitions during adolescence and adulthood. White blood cell count remained relatively constant over life, whereas fibrinogen increased slightly, requiring distinct age and sex partitions. CONCLUSIONS The robust dataset generated in this study has allowed observation of dynamic biological profiles of several hematology markers and the establishment of comprehensive age- and sex-specific reference intervals that may contribute to accurate monitoring of pediatric, adult, and geriatric patients.

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Section: Discussionsupporting

confidence: 93%

Complex Biological Profile of Hematologic Markers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

et al. 2015

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“…The reference interval for hemoglobin concentration is higher than the usually accepted values [16,17], but are similar to the reference intervals presented in a new study [18]. The strict control of pre-analytical factors might explain our higher red cell reference intervals compared with some of those studies.…”

Section: Resultssupporting

confidence: 82%

The largest reference range study for hematological parameters from Turkey: A case control study

Tekkeşin

Beköz²,

Tükenmez³

2014

J Clin Exp Invest

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Objective: Accurate, reliable laboratory reference ranges are essential for effective clinical evaluation and monitoring. We present robust reference ranges established for hematology parameters using the Sysmex XT2000i analyzer.Methods: Blood samples were taken from 17409 healthy adults (19 to 49 years, 51.4% men and 48.6% women) and routine hematology analysis performed. Patients were assessed as healthy on the basis of a medical history and routine medical examinations. Serum hematinic assays (vitamin B12, folate, iron and ferritin) were also analyzed in order to exclude the potential anemia existence.Results: There was a statistically significant difference (p<0.001) between men and women, with the former showing higher CBC values, except WBC, neutrophil and platelet counts compared to females. Several differences were observed when compared to previously established values from Turkey, most notably in leucocytes and platelets. Our findings for CBC parameters, except leucocyte count and MCV are in general agreement with previously published data from more limited trials undertaken in other countries. Conclusions:In spite of the uncontrolled factors influencing hematological values, this study permitted to establish the new hematological reference values in Turkey, especially living near sea level. In the absence of previously detailed investigated hematological reference values in Turkey, we offered to use these results for clinical management of Turkish patients and interpretations of laboratory data for research purpose. J Clin Exp Invest 2014; 5 (4): 548-552

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“…It is of interest to report also that the reference values of MCV and WBC from the current study were on most occasions far lower than those of other European countries [25]. Similar results of MCV, WBC, Hb, PCV and RBC with varying degrees have been made in studies carried out in other ethnic groups such as Palestine [21], Tanzania [19], Sudan [28], Kenya [29], Nigeria, and Turkey [30].…”

Section: Discussionsupporting

confidence: 83%

“…Our findings reflect that healthy adults from the Aljouf region have also some hematological parameters differing quantitatively from Arab [19,21], Caucasians [25,26], Asian [23,27] and African [20,28,29], while other hematological parameters have reference value profiles which are similar to these ethnic groups [18,20,21,23,26,27,29].…”

Section: Discussionsupporting

confidence: 68%

Reference Value Profile for Healthy Individuals From the Aljouf region of Saudi Arabia

Elderdery¹,

Alshaiban²

2017

J Hematol

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Robust, routine haematology reference ranges for healthy adults

Cited by 61 publications

References 6 publications

Complex Biological Profile of Hematologic Markers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

Complex Biological Profile of Hematologic Markers across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey

The largest reference range study for hematological parameters from Turkey: A case control study

Reference Value Profile for Healthy Individuals From the Aljouf region of Saudi Arabia

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