Robust perceptual-load-dependent audiovisual integration in adult ADHD

Schulze, Marcel; Aslan, Behrem; Jung, Peter; Lux, Silke; Philipsen, Alexandra

doi:10.1007/s00406-022-01401-z

Cited by 5 publications

(5 citation statements)

References 52 publications

(47 reference statements)

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“…While we investigated possible aberrancies in early stages of sensory processing, Cross-Villasana et al (2015) measured delayed posterior contralateral negativity waves in adults with ADHD, indicating slower attentional selection in later stages of sensory processing. In addition to the impairment of unimodal visual processing in adults with ADHD, there is evidence that multisensory integration processes are aberrant as well, which were not investigated in this study (Schulze et al, 2020(Schulze et al, , 2021(Schulze et al, , 2022.…”

Section: Discussionmentioning

confidence: 86%

Electrophysiological evidence for increased auditory crossmodal activity in adult ADHD

Schramm,

Goregliad Fjaellingsdal,

Aslan

et al. 2023

Front. Neurosci.

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BackgroundAttention deficit and hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by core symptoms of inattention, and/or impulsivity and hyperactivity. In order to understand the basis for this multifaceted disorder, the investigation of sensory processing aberrancies recently reaches more interest. For example, during the processing of auditory stimuli comparable low sensory thresholds account for symptoms like higher distractibility and auditory hypersensitivity in patients with ADHD. It has further been shown that deficiencies not only exist on an intramodal, but also on a multimodal level. There is evidence that the visual cortex shows more activation during a focused auditory task in adults with ADHD than in healthy controls. This crossmodal activation is interpreted as the reallocation of more attentional resources to the visual domain as well as deficient sensory inhibition. In this study, we used, for the first time, electroencephalography to identify a potential abnormal regulated crossmodal activation in adult ADHD.Methods15 adult subjects with clinically diagnosed ADHD and 14 healthy controls comparable in age and gender were included. ERP components P50, P100, N100, P200 and N200 were measured during the performance of a unimodal auditory and visual discrimination task in a block design. Sensory profiles and ADHD symptoms were assessed with inattention as well as childhood ADHD scores. For evaluating intramodal and crossmodal activations, we chose four EEG channels for statistical analysis and group-wise comparison.ResultsAt the occipital channel O2 that reflects possible crossmodal activations, a significantly enhanced P200 amplitude was measured in the patient group. At the intramodal channels, a significantly enhanced N200 amplitude was observed in the control group. Statistical analysis of behavioral data showed poorer performance of subjects with ADHD as well as higher discrimination thresholds. Further, the correlation of the assessed sensory profiles with the EEG parameters revealed a negative correlation between the P200 component and sensation seeking behavior.ConclusionOur findings show increased auditory crossmodal activity that might reflect an altered stimulus processing resource allocation in ADHD. This might induce consequences for later, higher order attentional deployment. Further, the enhanced P200 amplitude might reflect more sensory registration and therefore deficient inhibition mechanisms in adults with ADHD.

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Section: Discussionmentioning

confidence: 86%

Electrophysiological evidence for increased auditory crossmodal activity in adult ADHD

Schramm,

Goregliad Fjaellingsdal,

Aslan

et al. 2023

Front. Neurosci.

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“…To obtain a coherent perception, our brain combines different sensory modalities–a process that is called multisensory integration (MI) [ 8 ]. Only a few studies have investigated MI in ADHD, reporting mixed results [ 9 , 10 , 11 , 12 ]. Overall, these studies can be summarized with regard to the stimuli quality employed.…”

Section: Introductionmentioning

confidence: 99%

Network-Based Differences in Top–Down Multisensory Integration between Adult ADHD and Healthy Controls—A Diffusion MRI Study

et al. 2023

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Background: Attention-deficit–hyperactivity disorder (ADHD) is a neurodevelopmental disorder neurobiologically conceptualized as a network disorder in white and gray matter. A relatively new branch in ADHD research is sensory processing. Here, altered sensory processing i.e., sensory hypersensitivity, is reported, especially in the auditory domain. However, our perception is driven by a complex interplay across different sensory modalities. Our brain is specialized in binding those different sensory modalities to a unified percept—a process called multisensory integration (MI) that is mediated through fronto-temporal and fronto-parietal networks. MI has been recently described to be impaired for complex stimuli in adult patients with ADHD. The current study relates MI in adult ADHD with diffusion-weighted imaging. Connectome-based and graph-theoretic analysis was applied to investigate a possible relationship between the ability to integrate multimodal input and network-based ADHD pathophysiology. Methods: Multishell, high-angular resolution diffusion-weighted imaging was performed on twenty-five patients with ADHD (six females, age: 30.08 (SD: 9.3) years) and twenty-four healthy controls (nine females; age: 26.88 (SD: 6.3) years). Structural connectome was created and graph theory was applied to investigate ADHD pathophysiology. Additionally, MI scores, i.e., the percentage of successful multisensory integration derived from the McGurk paradigm, were groupwise correlated with the structural connectome. Results: Structural connectivity was elevated in patients with ADHD in network hubs mirroring altered default-mode network activity typically reported for patients with ADHD. Compared to controls, MI was associated with higher connectivity in ADHD between Heschl’s gyrus and auditory parabelt regions along with altered fronto-temporal network integrity. Conclusion: Alterations in structural network integrity in adult ADHD can be extended to multisensory behavior. MI and the respective network integration in ADHD might represent the maturational cortical delay that extends to adulthood with respect to sensory processing.

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“…Specifically, the information from both visual and auditory channels are integrated effectively into a unified and coherent perceptual process [1]. Research shows that cognitive dysfunction of a special population is associated with audiovisual integration function, such as hearing loss [2], Alzheimer's disease [3], autism [4], attention deficit disorder [5], etc.…”

Section: Introductionmentioning

confidence: 99%

Dynamic brain causal connectivity of audiovisual integration under endogenous attention regulation

Yan

Guan

et al. 2023

International Conference on Image, Signal Processing, and Pattern Recognition (ISPP 2023)

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The dorsolateral frontoparietal network (frontal eye field (FEF) and inferior parietal lobule (IPL)) has been proven related to endogenous attention, while the superior temporal gyrus (STG) has been proven related to audiovisual integration. However, the dynamic causal mechanism of these three brain regions in the process of audiovisual integration under endogenous attention regulation is still unclear. To explore the dynamic brain connection of audiovisual integration under endogenous attention regulation, functional magnetic resonance imaging(fMRI) data were collected from 49 young normal participants (mean age 23 years) when accomplishing three tasks of only audio (A), only visual (V), and audiovisual attention (VA) task under the endogenous attention. 15 models were established utilizing dynamic causal modelling and the optimal model was obtained by the Bayesian model selection. The difference in effective connectivity of the optimal model under different tasks was compared to both hemispheres respectively. We found the optimal models of three tasks in both hemispheres were all STG-oriented driving-inputs, and the modulations were fully-connected models. The paired t-test showed there were significant differences in IPL→FEF, and STG→FEF between the VA and A task in the left hemisphere, and IPL→FEF, STG→FEF, FEF→STG between the VA and V task in the right. It concluded that the audiovisual integration process under the endogenous attention regulation depends on the collaboration of the frontoparietal network and the superior temporal gyrus. The enhanced connection within frontoparietal networks would play a role in distributing attention to different modalities, and the superior temporal gyrus deals with specific stimuli contents.

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Robust perceptual-load-dependent audiovisual integration in adult ADHD

Cited by 5 publications

References 52 publications

Electrophysiological evidence for increased auditory crossmodal activity in adult ADHD

Electrophysiological evidence for increased auditory crossmodal activity in adult ADHD

Network-Based Differences in Top–Down Multisensory Integration between Adult ADHD and Healthy Controls—A Diffusion MRI Study

Dynamic brain causal connectivity of audiovisual integration under endogenous attention regulation

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