Robust Packing of a Self‐Assembling Iridium Complex via Endocytic Trafficking for Long‐Term Lysosome Tracking

Abstract

Figure 4. a) Fluorescent images of self-assembled Irpc (green) and DAPI (blue) in a HeLa cell under fed (left) and starved conditions (right). b) Time-lapse SIM images of a HeLa cell treated with Irpc (2 mM/20 min) co-stained with MitoTracker Deepred.

A pH-responsive iridium(iii) two-photon photosensitizer loaded CaCO3 nanoplatform for combined Ca2+ overload and photodynamic therapy

“…25,26 Capitalizing on these promising properties, iridium(III) coordination complexes have been investigated as two-photon near-infrared excited photosensitizers for photodynamic therapy, [27][28][29][30][31] luminescent probes for the detection of specific cellular processes, [32][33][34][35][36] or cellular dyes. 37,38 However, due to the poor tumor selectivity of the molecular iridium(III) complexes upon intravenous injection into the bloodstream, these compounds could only find an application by local intratumoral injection, thus limiting their application. To overcome this drawback as well as reduce the potential dark toxicity, these metal complexes could be incorporated into a tumor-targeting nanoplatform, presenting a selective and therapeutically enhanced effect.…”