Abstract:In this paper, a robust finite-time fault-tolerant control (FTC) scheme is developed for uncertain linear systems in the presence of actuator faults. Since the system uncertainties and actuator faults are unknown, the controller parameters are updated online by the adaptive laws without the need for fault detection and isolation. It is proved that the proposed state-feedback model reference adaptive finite-time FTC scheme can guarantee that the tracking error converges to a small neighborhood of the origin in … Show more
“…e stability of the closed-loop system with reconstructed measurements needs to be proved. erefore, with application to quadrotor helicopters, the fault diagnosis and fault-tolerant control for quadrotor helicopters has been an important research topic in recent years with the growing demands for safety, reliability, and maintainability [16][17][18]. e timely diagnosis and correction of faults in a quadrotor system are critical in avoiding abnormal system performance and reducing the unexpected accidents significantly.…”
This paper presents an active fault-tolerant control strategy for quadrotor helicopters to simultaneously accommodate sensor faults and external disturbances. Unlike most of the existing fault diagnosis and fault-tolerant control schemes for quadrotor helicopters, the proposed fault diagnosis scheme is able to estimate sensor faults while eliminating the effect of external disturbances. Moreover, the proposed fault-tolerant control scheme is capable to eliminate the adverse effect of external disturbances as well by designing a disturbance observer to effectively estimate the unknown external disturbances and integrating with the designed integral sliding-mode controller. In this case, the continuous operation of the quadrotor helicopter is ensured while avoiding the unexpected control chattering. In addition, the stability of the closed-loop system is theoretically proved. Finally, the effectiveness and advantages of the proposed scheme are validated and demonstrated through comparative numerical simulations of the quadrotor helicopter under different faulty and uncertain scenarios.
“…e stability of the closed-loop system with reconstructed measurements needs to be proved. erefore, with application to quadrotor helicopters, the fault diagnosis and fault-tolerant control for quadrotor helicopters has been an important research topic in recent years with the growing demands for safety, reliability, and maintainability [16][17][18]. e timely diagnosis and correction of faults in a quadrotor system are critical in avoiding abnormal system performance and reducing the unexpected accidents significantly.…”
This paper presents an active fault-tolerant control strategy for quadrotor helicopters to simultaneously accommodate sensor faults and external disturbances. Unlike most of the existing fault diagnosis and fault-tolerant control schemes for quadrotor helicopters, the proposed fault diagnosis scheme is able to estimate sensor faults while eliminating the effect of external disturbances. Moreover, the proposed fault-tolerant control scheme is capable to eliminate the adverse effect of external disturbances as well by designing a disturbance observer to effectively estimate the unknown external disturbances and integrating with the designed integral sliding-mode controller. In this case, the continuous operation of the quadrotor helicopter is ensured while avoiding the unexpected control chattering. In addition, the stability of the closed-loop system is theoretically proved. Finally, the effectiveness and advantages of the proposed scheme are validated and demonstrated through comparative numerical simulations of the quadrotor helicopter under different faulty and uncertain scenarios.
AbstractBase editors are chimeric ribonucleoprotein complexes consisting of a DNA-targeting CRISPR-Cas module and a single-stranded DNA deaminase. They enable conversion of C•G into T•A base pairs and vice versa on genomic DNA. While base editors have vast potential as genome editing tools for basic research and gene therapy, their application has been hampered by a broad variation in editing efficiencies on different genomic loci. Here we perform an extensive analysis of adenine- and cytosine base editors on thousands of lentivirally integrated genetic sequences and establish BE-DICT, an attention-based deep learning algorithm capable of predicting base editing outcomes with high accuracy. BE-DICT is a versatile tool that in principle can be trained on any novel base editor variant, facilitating the application of base editing for research and therapy.
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