In the design of the control law due to sensor and actuator faults, it is very important to implement the fault tolerant control system. Unknown Input Observers (UIO) can be used in model based fault detection and isolation (FDI) schemes to reduce or almost eliminate the effect of unknown disturbances on the MIMO (Multiple-Input and Multiple-Output) plant/system. Furthermore, they can be used to generate residuals that are insensitive to unknown disturbances or noise, and thus, lower the false alarm rate. Design of many faults isolation banks of UIOs has been done. To make sure the best detection and isolation of the faults is provided, these banks generate residuals which are sensitive to only one fault. Fault tolerant control is used to compensate both sensor and actuator faults.