In this article, we study the coexistence and optimization of a centralized orthogonal frequency-division multiple access-based multiuser cognitive radio (MCR) system which coexists with a cellular primary system (PS). Two different spectrum sharing methods, i.e., the spectrum underlay/overlay, are utilized for different coexistent frameworks, in which, the sharing method is adapted to one of them based on the distance between two base stations and the interference limit in the PS. We consider a PS-assistance-based coexistent architecture and propose a joint power control and interference management method to avoid unacceptable interference to primary users (PU). Firstly, the relationship between power limits at secondary users (SU) and interference margin at PUs can be obtained. Then, to provide the SUs with satisfactory quality of service (QoS), and optimize the sum rate of the MCR system as well, a constrained two-variable nonlinear optimization problem (OP) is formulated. We solve this OP by (i) simplifying the QoS constraints from medium access control-layer to physical-layer based on a crosslayer approximation; and (ii) using the Lagrangian duality based technique to solve the simplified OP, and iterative water-filling is implemented to find the optimal power and subcarrier allocation. Simulation results show that, compared to the conventional designs, our algorithm achieves significant higher throughput and can guarantee the required signal to interference plus noise ratio of the PUs and the QoS of the SUs well. Moreover, compared to the spectrum overlay sharing method, the spectrum underlay & overlay can provide substantial higher spectrum efficiency.