Robust data storage in DNA by de Bruijn graph-based de novo strand assembly

Song, Lifu; Geng, Feng; Gong, Zi-Yi; Chen, Xin; Tang, Jijun; Gong, Chunye; Zhou, Libang; Xia, Rui; Han, Mingzhe; Xu, Jing-Yi; Li, Bing‐Zhi; Yuan, Ying‐Jin

doi:10.1038/s41467-022-33046-w

Cited by 33 publications

(52 citation statements)

References 56 publications

(57 reference statements)

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“…All that is required is to encode P 3 with a fountain code prior to dynamic modulation encryption. To the best of our knowledge, such robustness can only be achieved by modulation-based DNA storage architecture ( Yazdi et al, 2017 ; Antkowiak et al, 2020 ; Press et al, 2020 ; Srinivasavaradhan et al, 2021 ; Song et al, 2022 ; Zan et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

An image cryptography method by highly error-prone DNA storage channel

Zan

Chu

Xie

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: Rapid development in synthetic technologies has boosted DNA as a potential medium for large-scale data storage. Meanwhile, how to implement data security in the DNA storage system is still an unsolved problem.Methods: In this article, we propose an image encryption method based on the modulation-based storage architecture. The key idea is to take advantage of the unpredictable modulation signals to encrypt images in highly error-prone DNA storage channels.Results and Discussion: Numerical results have demonstrated that our image encryption method is feasible and effective with excellent security against various attacks (statistical, differential, noise, and data loss). When compared with other methods such as the hybridization reactions of DNA molecules, the proposed method is more reliable and feasible for large-scale applications.

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Section: Resultsmentioning

confidence: 99%

An image cryptography method by highly error-prone DNA storage channel

Zan

Chu

Xie

et al. 2023

Front. Bioeng. Biotechnol.

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“…5(b) shows the decrypted images which could retain the portrait even with loss rate 50%. To the best of our knowledge, such robustness can only be achieved by modulation-based DNA storage architecture [3, 5, 18, 27–29].…”

Section: Resultsmentioning

confidence: 99%

An image cryptography method in highly error-prone DNA storage channel

Zan

Xie

Chu

et al. 2022

Preprint

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Rapid development in synthetic technologies has boosted DNA as a potential medium for large-scale data storage. Meanwhile, how to implement data security in DNA storage system is still an unsolved problem. In this paper, we propose an image encryption method based on the modulation-based storage architecture. The key idea is to take advantage of the unpredictable modulation signals to encrypt image in highly error-prone DNA storage channel. Numerical results demonstrate that our image encryption method is feasible and effective with excellent security against various attacks (statistical, differential, noise and data loss, etc.). Compared with other methods by DNA molecules hybridization reaction, the proposed method is more reliable and feasible for large-scale applications.

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“…We synthesized DNA tape registers in bacteria en-masse, therefore DMOS has the potential to bypasses some challenges of conventional DNA based data storage including generation of toxic wastes, scalability, editability, and rewritability. [23][24][25][26][27][28][29][30] E.g., in most systems DNA is chemically synthesized, user needs access to DNA synthesizer machines in order to write a new data, and editing of the recorded data requires the synthesis of the whole or significant portions of the DNA pools. Since majority of these challenges are due to the need for de-novo DNA synthesis, a few efforts have focused on alternative DNA based storage media.…”

Section: Discussionmentioning

confidence: 99%

Digital data storage on DNA tape using CRISPR base editors

Sadremomtaz

Glass

Guerrero

et al. 2023

Preprint

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While the archival digital memory industry approaches its physical limits, the demand is significantly increasing, therefore alternatives emerge. Recent efforts have demonstrated DNA's enormous potential as a digital storage medium with superior information durability, capacity, and energy consumption. However, the majority of the proposed systems require on-demand de-novo DNA synthesis techniques that produce a large amount of toxic waste and therefore are not industrially scalable and environmentally friendly. Inspired by the architecture of semiconductor memory devices and recent developments in gene editing, we created a molecular digital data storage system called 'DNA Mutational Overwriting Storage' (DMOS) that stores information by leveraging combinatorial, addressable, orthogonal, and independent in vitro CRISPR base-editing reactions to write data on a blank pool of greenly synthesized DNA tapes. As a proof of concept, we wrote both a bitmap representation of our school's logo and the title of this study on the DNA tapes, and accurately recovered the stored data.

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Robust data storage in DNA by de Bruijn graph-based de novo strand assembly

Cited by 33 publications

References 56 publications

An image cryptography method by highly error-prone DNA storage channel

An image cryptography method by highly error-prone DNA storage channel

An image cryptography method in highly error-prone DNA storage channel

Digital data storage on DNA tape using CRISPR base editors

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