Robust and Adaptive Deep Model Ensemble Framework Fine-tuned by Structural Information for Drug-Target Interactions
Jinhang Wei,
Linlin Zhuo,
Xiangzheng Fu
et al.
Abstract:In the fields of new drug development and drug repositioning, drug-target interactions (DTI) play a pivotal role. Although deep learning models have already made significant contributions in this domain, the state-of-the-art models still exhibit shortcomings in predictive performance and issues of false-negative errors. Based on these observations, we constructed a streamlined yet effective base learner model. With our designed adaptive feature weight network, the model can capture key features within drugs (t… Show more
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