Robotic system for magnetic resonance imaging‐guided focused ultrasound treatment of thyroid nodules

Filippou, Antria; Evripidou, Nikolas; Damianou, Christakis

doi:10.1002/rcs.2525

Cited by 6 publications

(2 citation statements)

References 115 publications

(272 reference statements)

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“…Further, navigational tools can be tested by ablating predefined planned points and measuring how accurately those positions have been reached. This phantom allows for more avenues to be explored 19 and to expedite the process of developing new technologies for thermal ablations in thyroid nodules.…”

Section: Discussionmentioning

confidence: 99%

“…18 For the thermal ablation studies, one phantom was produced for a magnetic resonance imaging (MRI) compatible high-intensity focused ultrasound system. 19 Another phantom was produced for an RFA study comparing various ultrasound transducers. 13 The materials used in phantoms vary as well, where the literature reports water-based, oil-based as well as plastic materials.…”

Section: Introductionmentioning

confidence: 99%

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An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules

Boers,

Brink,

Bianchi

et al. 2023

Medical Physics

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BackgroundNeedle‐based procedures, such as fine needle aspiration and thermal ablation, are often applied for thyroid nodule diagnosis and therapeutic purposes, respectively. With blood vessels and nerves nearby, these procedures can pose risks in damaging surrounding critical structures.PurposeThe development and validation of innovative strategies to manage these risks require a test object with well‐characterized physical properties. For this work, we focus on the application of ultrasound‐guided thermal radiofrequency ablation.MethodsWe have developed a single‐use anthropomorphic phantom mimicking the thyroid and surrounding anatomical and physiological structures that are relevant to ultrasound‐guided thermal ablation. The phantom was composed of a mixture of polyacrylamide, water, and egg white extract and was cast using molds in multiple steps. The thermal, acoustical, and electrical characteristics were experimentally validated. The ablation zones were analyzed via non‐destructive T2‐weighted magnetic resonance imaging scans utilizing the relaxometry changes of coagulated egg albumen, and the temperature distribution was monitored using an array of fiber Bragg grating sensors.ResultsThe physical properties of the phantom were verified both on ultrasound as well as in terms of the phantom response to thermal ablation. The final temperature achieved (92°C), the median percentage of the nodule ablated (82.1%), the median volume ablated outside the nodule (0.8 mL), and the median number of critical structures affected (0) were quantified.ConclusionAn anthropomorphic phantom that can provide a realistic model for development and training in ultrasound‐guided needle‐based thermal interventions for thyroid nodules has been presented.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules

Boers,

Brink,

Bianchi

et al. 2023

Medical Physics

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Update on musculoskeletal applications of magnetic resonance-guided focused ultrasound

McGill,

Baal,

Bucknor

2024

Skeletal Radiol

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Magnetic resonance-guided focused ultrasound (MRgFUS) is a noninvasive, incisionless, radiation-free technology used to ablate tissue deep within the body. This technique has gained increased popularity following FDA approval for treatment of pain related to bone metastases and limited approval for treatment of osteoid osteoma. MRgFUS delivers superior visualization of soft tissue targets in unlimited imaging planes and precision in targeting and delivery of thermal dose which is all provided during real-time monitoring using MR thermometry. This paper provides an overview of the common musculoskeletal applications of MRgFUS along with updates on clinical outcomes and discussion of future applications.

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Focused ultrasound heating in brain tissue/skull phantoms with 1 MHz single-element transducer

2023

Self Cite

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Purpose The study aims to provide insights on the practicality of using single-element transducers for transcranial Focused Ultrasound (tFUS) thermal applications. Methods FUS sonications were performed through skull phantoms embedding agar-based tissue mimicking gels using a 1 MHz single-element spherically focused transducer. The skull phantoms were 3D printed with Acrylonitrile Butadiene Styrene (ABS) and Resin thermoplastics having the exact skull bone geometry of a healthy volunteer. The temperature field distribution during and after heating was monitored in a 3 T Magnetic Resonance Imaging (MRI) scanner using MR thermometry. The effect of the skull’s thickness on intracranial heating was investigated. Results A single FUS sonication at focal acoustic intensities close to 1580 W/cm2 for 60 s in free field heated up the agar phantom to ablative temperatures reaching about 90 °C (baseline of 37 °C). The ABS skull strongly blocked the ultrasonic waves, resulting in zero temperature increase within the phantom. Considerable heating was achieved through the Resin skull, but it remained at hyperthermia levels. Conversely, tFUS through a 1 mm Resin skull showed enhanced ultrasonic penetration and heating, with the focal temperature reaching 70 °C. Conclusions The ABS skull demonstrated poorer performance in terms of tFUS compared to the Resin skull owing to its higher ultrasonic attenuation and porosity. The thin Resin phantom of 1 mm thickness provided an efficient acoustic window for delivering tFUS and heating up deep phantom areas. The results of such studies could be particularly useful for accelerating the establishment of a wider range of tFUS applications.

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Robotic system for magnetic resonance imaging‐guided focused ultrasound treatment of thyroid nodules

Cited by 6 publications

References 115 publications

An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules

An anthropomorphic thyroid phantom for ultrasound‐guided radiofrequency ablation of nodules

Update on musculoskeletal applications of magnetic resonance-guided focused ultrasound

Focused ultrasound heating in brain tissue/skull phantoms with 1 MHz single-element transducer

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