Robotic radiosurgery of head and neck paragangliomas: a single institution experience

Tosun, İlker; Atalar, Banu; Sahin, Betul; Güngör, Görkem; Aydin, Gokhan; Yapıcı, Bülent; Özyar, Enis

doi:10.1111/ajco.12695

Cited by 10 publications

(11 citation statements)

References 26 publications

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“…For the LC and late toxicity analysis only data from 76 patients irradiated for 77 lesions was available and presented in this study. Ten patients were also included in a study at their local institution …”

Section: Methodscontrasting

confidence: 51%

Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study

et al. 2019

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Background Paraganglioma of the head and neck (HNPGL) are rare often benign tumors. Surgery and radiation therapy (RT) are the main treatment choices. We present an analysis of outcome and toxicity after RT from 13 institutions of the Rare Cancer Network. Methods Data were collected using a questionnaire concerning patients' characteristics, treatment, and outcome. A total of 81 patients with 82 HNPGL were analyzed. Results The median follow‐up was 48 months (1‐456). Sixty‐two lesions were treated with conventional RT and 20 lesions with stereotactic RT. Local control (LC) was achieved in 69 out of 77 lesions. Late toxicity occurred in 17 patients. Patients treated with stereotactic RT experienced neither disease progression nor late toxicity. Four patients with a follow‐up longer than 20 years experienced disease progression. Conclusion RT for HNPGL offered good local control with acceptable toxicity. Stereotactic RT might offer better results. Long‐term follow‐up is required.

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Section: Methodscontrasting

confidence: 51%

Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study

et al. 2019

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“…For radiation treatment delivery, patients were immobilised with customized thermoplastic masks and personalized rest neck. Then, a 1 mm slice computed tomography (CT)-scan was performed and fused with T1- and T2-weighthed sequences 8 . Target volumes were identified as follows: gross tumour volume (GTV) was defined according to the area of contrast enhancement on CT and magnetic resonance imaging (MRI) (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Planning target volume (PTV) was generated by adding a 3 mm homogeneous margin to the CTV. In case of radiosurgery, CTV corresponded to GTV, and a median margin of 3 mm was outlined to generate PTV, based on the machine used for delivery and on the accuracy of the immobilization system and imaging modality used to verify patient set-up 816 .…”

Section: Resultsmentioning

confidence: 99%

Surgery of the lateral skull base: a 50-year endeavour

Zanoletti¹,

Mazzoni²,

Martini³

et al. 2019

Acta Otorhinolaryngol Ital

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SUMMARY Disregarding the widely used division of skull base into anterior and lateral, since the skull base should be conceived as a single anatomic structure, it was to our convenience to group all those approaches that run from the antero-lateral, pure lateral and postero-lateral side of the skull base as “Surgery of the lateral skull base”. “50 years of endeavour” points to the great effort which has been made over the last decades, when more and more difficult surgeries were performed by reducing morbidity. The principle of lateral skull base surgery, “remove skull base bone to approach the base itself and the adjacent sites of the endo-esocranium”, was then combined with function preservation and with tailoring surgery to the pathology. The concept that histology dictates the extent of resection, balancing the intrinsic morbidity of each approach was the object of the first section of the present report. The main surgical approaches were described in the second section and were conceived not as a step-by-step description of technique, but as the highlighthening of the surgical principles. The third section was centered on open issues related to the tumor and its treatment. The topic of vestibular schwannoma was investigated with the current debate on observation, hearing preservation surgery, hearing rehabilitation, radiotherapy and the recent efforts to detect biological markers able to predict tumor growth. Jugular foramen paragangliomas were treated in the frame of radical or partial surgery, radiotherapy, partial “tailored” surgery and observation. Surgery on meningioma was debated from the point of view of the neurosurgeon and of the otologist. Endolymphatic sac tumors and malignant tumors of the external auditory canal were also treated, as well as chordomas, chondrosarcomas and petrous bone cholesteatomas. Finally, the fourth section focused on free-choice topics which were assigned to aknowledged experts. The aim of this work was attempting to report the state of the art of the lateral skull base surgery after 50 years of hard work and, above all, to raise questions on those issues which still need an answer, as to allow progress in knowledge through sharing of various experiences. At the end of the reading, if more doubts remain rather than certainties, the aim of this work will probably be achieved.

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“…The resection possibility after RT has not been mentioned. Tosun recently reported 12 patients with head and neck paragangliomas, six of which were CBT [15]. All of them received fractionated stereotactic radiotherapy with CyberKnife ® up to a total median dose of 24 Gy.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Carotid Body Tumor Treated with Primary Radiotherapy and Resected Subsequently: Report of a Case and Review of the Literature

Salazar¹,

Pacheco-Ojeda²,

Mario³

et al. 2020

SCR

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Carotid body tumors (CBT) are rare benign neoplasms of neural crest origin arising from paraganglia cells located at carotid bifurcation. They are usually treated with surgery and occasionally with radiotherapy (RT) as a definitive treatment. We report a case of a carotid body tumor (CBT) in a 45-year old woman who was treated with RT at another institution with intent of diminishing its size and eventually be operated later. This tumor, located on the left side of the neck, appeared 3 years before and was associated with dysphagia and odynophagia. A computed tomography (CT) revealed a lesion of 4.7 cm in size. The patient received 54 Gy of RT. As the tumor persisted clinically, an angio-CT performed one year later showed a left CBT of the same size and a contralateral lesion of 2cm. The surgical resection of this smaller right lesion was performed first and, of the persistent left lesion, one month later. No technical difficulties were found on the resection of the latter tumor and rather decreased peripheral vascularization was present. The histological findings revealed changes due to RT. In an exhaustive review of the literature, there were no findings of any report of surgical resection of a CBT after the primary RT.

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Robotic radiosurgery of head and neck paragangliomas: a single institution experience

Abstract: Stereotactic radiotherapy is a good alternative to surgery for the treatment of head and neck paragangliomas coming up with a clear benefit of acute and late side effects. CyberKnife seems to be a safe and efficient system treating head and neck paragangliomas.

Cited by 10 publications

References 26 publications

Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study

Paraganglioma of the head and neck region, treated with radiation therapy, a Rare Cancer Network study

Surgery of the lateral skull base: a 50-year endeavour

Bilateral Carotid Body Tumor Treated with Primary Radiotherapy and Resected Subsequently: Report of a Case and Review of the Literature

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