Robotic Partial Left Hepatectomy for Metastatic Colon Cancer to the Liver. Application of Minimally Invasive Technique in Cancer Surgery

Sucandy, Iswanto; Giovannetti, Andres; Spence, Janelle; Ross, Sharona; Rosemurgy, Alexander S.

doi:10.1177/0003134820952873

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Over the past few decades, the mortality rate of colon cancer has been on the rise due to a general improvement in living standards and changes in lifestyle ( Sung et al, 2021 ). With the widespread availability of early screening, improving treatment options (including immunotherapy, surgical resection, chemotherapy and radiotherapy), and the discovery of new biomarkers, the prognosis of CC patients has improved significantly ( Lemini et al, 2019 ; Sucandy et al, 2020 ; Guevara-Cuellar et al, 2021 ). However, given that the 5-year survival rate (OS) of CC is relatively high, more and more researches have investigated the influencing factors for CC prognosis.…”

Section: Introductionmentioning

confidence: 99%

Survival Nomogram for Metastasis Colon Cancer Patients Based on SEER Database

Tai

Xue

et al. 2022

Front. Genet.

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Introduction: A prediction model for the 1-, 3-, and 5-year survival rates of metastatic colon cancer (mCC) patients was developed by analyzing important risk factors for the prognosis of mCC patients based on the SEER database.Method: The characteristic of 10,946 patients diagnosed with mCC between 2010 and 2015 was obtained from the SEER database. The population was randomly divided into a training cohort and an internal validation cohort in a 7:3 ratio. Univariate and multivariate cox for independent predictors of mCC prognosis were performed, and nomogram was constructed. The accuracy of the model was verified by calibration curves, ROC curves, and C-index, and the clinical utility of the model was analyzed using decision analysis curves.Result: Age, primary site, grade, surgery, and other eight factors were significantly associated with the prognosis of mCC patients, and these predictors were included in the construction of the nomogram. The C-index was 0.731 (95% CI 0.725–0.737) and 0.736 (95% CI 0.726–0.746) for the training cohort and the validation set, respectively. The results of the ROC curve analysis indicated that the area under the curve (AUC) exceeded 0.7 for both the training cohort and the validation set at 1, 3, and 5 years.Conclusion: The constructed prediction model had an excellent predictive accuracy, which will help clinical decision-making of mCC patients after surgery and individualized treatment.

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Section: Introductionmentioning

confidence: 99%

Survival Nomogram for Metastasis Colon Cancer Patients Based on SEER Database

Tai

Xue

et al. 2022

Front. Genet.

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“…Hepatectomy is one of the most important treatment methods for liver surgery diseases, especially for primary or metastatic liver malignant tumor diseases; surgical resection is not only the preferred treatment method but also the only possible to achieve a cure ( Sucandy et al, 2020 ). In the past 30 years, with the development of liver surgery, improvement of surgical techniques, and standardization of intraoperative and perioperative management, the restricted area of hepatectomy has been continuously broken through, and the success rate of operation has been significantly improved; in addition, the incidence of postoperative complications and mortality have decreased significantly ( Wei Chieh et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Liver Regeneration During ALPPS

Xiao

Peng

et al. 2022

Front. Cell Dev. Biol.

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Liver cancer is one of the most lethal malignant tumors in the world, and surgical resection is the main treatment for liver cancer. Liver failure due to insufficient residual liver volume is a fatal complication after hepatectomy. How to effectively increase the residual liver volume after hepatectomy and improve the safety of hepatectomy has always been a problem to be solved in liver surgery. Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) effectively reduces the occurrence of liver failure due to insufficient residual liver volume after hepatectomy, thereby increasing the probability of radical resection by inducing rapid proliferation of residual liver tissue. However, the molecular mechanism of residual liver tissue regeneration after primary ALPPS (combined liver partition and portal vein ligation) remains unclear. Here, we found that lots of circular RNAs (circRNAs) are upregulated after ALPPS in pig liver cells; then, we identified the orthologous circRNA in humans and pigs to detect their function in liver regeneration. The results showed that loss of circ-0067724 and circ-0016213 could suppress liver cell proliferation. Together, these findings suggest that circ-0067724 and circ-0016213 play an important role in liver cell proliferation, and this may help us to find new strategies to promote liver regeneration.

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Robotic Partial Left Hepatectomy for Metastatic Colon Cancer to the Liver. Application of Minimally Invasive Technique in Cancer Surgery

Cited by 2 publications

References 4 publications

Survival Nomogram for Metastasis Colon Cancer Patients Based on SEER Database

Survival Nomogram for Metastasis Colon Cancer Patients Based on SEER Database

Mechanism of Liver Regeneration During ALPPS

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