Background: In the treatment of patients with liver cancer, laparoscopic liver cancer resection is the earliest and most widely used minimally invasive surgery. Robotic surgery technology helps surgeons overcome the shortcomings of traditional laparoscopic surgery by providing surgeons with high-resolution 3D images, wrist instruments that provide degrees of freedom, and tremor filtering technology. Objective: We designed a cost-minimization analysis to explore the cost difference of roboticassisted versus laparoscopic-assisted liver cancer resection, so as to provide the valuable reference for clinical practice and patients. Results: A total of 51 patients performed with liver cancer were carefully chosen from Gansu Provincial People’s Hospital, which included eighteen patients with robot-assisted hepatectomy and thirty-three patients with laparoscopic-assisted hepatectomy. The Cost-minimization analysis showed that the average medical cost per patient receiving robotic surgery was 60,322 yuan, and the average medical cost per patient receiving laparoscopic surgery was 46,867 yuan. Compared with robotic surgery, laparoscopic surgery could save 13,455 yuan. Method: Cost-minimization analysis was designed to determine the best option economic for medical technology with the similarity of efficacy and safety for robotic hepatectomy and laparoscopic hepatectomy. Excel 2016 software was used to collect and analyze cost data. Oneway deterministic sensitivity analysis was performed to assess the uncertainty of the parameter (cost of operation, cost of medical materials, cost of adjuvant therapy, cost of medicine, cost of medical examination, cost of anesthesia, cost of health care, and cost of hospitalization) values and gauge the reliability and generalizability of the results. Conclusion: The comparison between robotic-assisted liver surgery and laparoscopic surgery shows that the average medical cost was higher in robotic surgery when compared to laparoscopic liver cancer.