Robotic blue-dye sentinel lymph node detection for endometrial cancer – Factors predicting successful mapping

Near-infrared fluorescence for detection of sentinel lymph nodes in women with cervical and uterine cancers (FILM): a randomised, phase 3, multicentre, non-inferiority trial

“…(6) However, blue dye alone detected bilateral lymph nodes in only 31% of patients, a rate lower than the 55% to 60% reported in previous studies. (18, 19) All surgeons participating in our study had attained proficiency in the mapping procedure, so it is difficult to attribute the low rate of detection of bilateral nodes with blue dye alone to poor technique or learning curve. Some might argue that the use of blue dye alone instead of combined blue dye and radiocolloid was responsible for the low rate of detection of bilateral sentinel nodes.…”

Sentinel Lymph Node Mapping in Endometrial Cancer: A Comprehensive Review

“…However, the blue dye can diffuse to parametrial area thus interfering with the discovery of regional SLN ( 31 ). Some methylene blue may leak into the capillaries, resulting in reduced dye volume in lymphatic pathway and decreased SLN DR ( 32 ). Also, the risk of allergy cannot be ignored ( 33 ).…”

Sentinel lymph node assessment in endometrial cancer: a systematic review and meta-analysis

“…a Includes 3 studies comparing ICG and blue dye, 12,22,28 2 comparing radiotracer with/without dye, 57,67 3 comparing cervical vs uterine injection, 41,49,76 5 comparing grade 1 vs grades 2e3, 22,27,29,37,64 and 5 comparing endometrioid and non-endometrioid histology. 22,27,29,37,64 Operating time and adverse events The additional operating time for SLN mapping compared with LND ranged from 3 to 40 minutes (6 studies). 23,28,35,43,44,55 One study reported lower blood loss with SLN mapping compared with LND.…”