Robot-assisted orthotopic and heterotopic ovarian tissue transplantation techniques: surgical advances since our first success in 2000

Oktay, Kutluk; Taylan, Enes; Kojima, Tai; Cillo, Giulia Maria

doi:10.1016/j.fertnstert.2018.11.042

Cited by 34 publications

(14 citation statements)

References 14 publications

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“…25 Furthermore, recurrent live births from spontaneous conception following subcutaneous ovarian transplants in patients with primary ovarian insufficiency (POI) have been reported and therefore the question assumed was whether the grafted tissue can augment the function of in situ menopausal ovary. 26 Heterologous ovarian tissue transplantation to the subcutaneous adipose tissue of the lower arm was performed in 1 patient in Germany, but no pregnancy occurred. 21 The main problem by heterotopic site is that it may not provide an optimal environment for follicle and oocyte development, possibly because of differences in temperature, pressure, paracrine factors, and blood supply.…”

Section: Surgical Technique and Transplantation Sitementioning

confidence: 99%

Ovarian Tissue Transplantation: Experience From Germany and Worldwide Efficacy

Lotz

Dittrich

Hoffmann

et al. 2019

Clin Med�Insights�Reprod�Health

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Extraction of ovarian tissue prior to oncologic therapy and subsequent transplantation is being performed increasingly often to preserve fertility in women. The procedure can be performed at any time of the cycle and, therefore, generally does not lead to any delay in oncological therapy. Success rates with transplantation of cryopreserved ovarian tissue have reached promising levels. More than 130 live births have been reported worldwide with the aid of cryopreserved ovarian tissue and the estimated birth rate is currently approximately 30%. In Germany, Austria, and Switzerland, the FertiPROTEKT consortium has successfully achieved 21 pregnancies and 17 deliveries generated after 95 ovarian tissue transplantations by 2015, one of the largest case series worldwide confirming that ovarian tissue cryopreservation and transplantation are successful. Approximately, more than 400 ovarian tissue cryopreservation procedures are performed each year in the FertiPROTEKT consortium, and the request and operations for ovarian tissue transplantation have increased in recent years. Therefore, recommendations for managing transplantation of ovarian tissue to German-speaking reproductive medicine centers were developed. In this overview, these recommendations and our experience in ovarian tissue transplantation are presented and discussed with international procedures.

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Section: Surgical Technique and Transplantation Sitementioning

confidence: 99%

Ovarian Tissue Transplantation: Experience From Germany and Worldwide Efficacy

Lotz

Dittrich

Hoffmann

et al. 2019

Clin Med�Insights�Reprod�Health

View full text Add to dashboard Cite

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“…Differential diagnosis of HP is wide: intrauterine gestation with a hemorrhagic corpus luteum can simulate H/E gestation both clinically and on ultrasound. A bicornuate uterus with gestation in both cavities and other surgical conditions of acute abdomen can also simulate HP [4,7,10].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Heterotopic Pregnancy as an Uncommon Clinical Problem

Stanić

Roje

Matić

et al. 2020

Z Geburtshilfe Neonatol

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Background Heterotopic pregnancy refers to the simultaneous coexistence of an intrauterine and extrauterine pregnancy. In natural conception it is very rare, with a rising incidence in patients undergoing assisted reproduction technologies. It presents a serious diagnostic problem which is often misdiagnosed. Currently, there are no standard protocols for the treatment and diagnosis of heterotopic pregnancy. Methods Two rare cases of spontaneous heterotopic pregnancy are presented. Result The first patient had a complete abortion upon which an extrauterine pregnancy was detected. The second patient, after an extrauterine pregnancy removal, progressed with an intrauterine pregnancy until full term and it ended with the delivery of a healthy infant. Conclusion Two demonstrated cases underscore that whenever abnormal adnexal findings are presented and the beta-hCG blood test is positive, the possibility of a heterotopic pregnancy should be suspected.

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“…As previously discussed, the choice between orthotopic or heterotopic graft sites depend on patient disease factors as well as any adjuvant therapies such as removal of ovaries or pelvic irradiation. Various surgical techniques such as robotic surgery and use of allografts such as Alloderm have also been trialled in an attempt to increase the success of follicular stimulation from OTT, but ongoing experimentation is likely to be required (44).…”

Section: Surgical Techniquesmentioning

confidence: 99%

Applying plastic surgery principles to ovarian tissue transplantation

et al. 2021

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Ovarian tissue cryopreservation (OTC) and transplantation is an innovative procedure increasingly utilized to help preserve fertility after gonadotoxic treatments especially in cancer patients.Approximately 30% of autotransplanted patients are able to achieve live birth, typically with the help of in-vitro fertilization. Numerous techniques and grafting sites have been described to continue to increase this figure. In the field of plastic surgery, tissue grafting has been successful performed for thousands of years and knowledge in this area has been significantly refined. A qualitative review of the literature using PubMed, Cochrane, SCOPUS and Medline databases was performed to look for articles relating to ovarian tissue transplantation (OTT) and comparisons made to plastic surgery tissue grafting. Many parallels were found between the principles of grafting in plastic surgery and the principles of OTT, including pre-operative patient optimization, suitable donor site selection, tissue harvest and preparation, graft site choice, immobilization of the graft and post-operative care. Consideration of the benefits and risks of using orthotopic versus heterotopic recipient sites is also highly important with regards to graft take, morbidity and ease of access of oocyte collection. We believe that ongoing discussion between disciplines can have the potential to improve knowledge, surgical techniques and patient outcomes.

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Robot-assisted orthotopic and heterotopic ovarian tissue transplantation techniques: surgical advances since our first success in 2000

Cited by 34 publications

References 14 publications

Ovarian Tissue Transplantation: Experience From Germany and Worldwide Efficacy

Ovarian Tissue Transplantation: Experience From Germany and Worldwide Efficacy

Spontaneous Heterotopic Pregnancy as an Uncommon Clinical Problem

Applying plastic surgery principles to ovarian tissue transplantation

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