Robo1 and Robo2 Control the Development of the Lateral Olfactory Tract

Fouquet, Coralie; Meglio, Thomas Di; Ma, Le; Kawasaki, Tadahiro; Long, Hua; Hirata, Tatsumi; Tessier‐Lavigne, Marc; Chédotal, Alain; Nguyen-Ba-Charvet, Kim T.

doi:10.1523/jneurosci.0172-07.2007

Cited by 47 publications

(52 citation statements)

References 59 publications

(66 reference statements)

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“…Therefore, Robo2 appears to have the strongest repulsive activity in this system, but Robo1 cooperates with Robo2 to prevent crossing. However, the Robo1 knock-out line used here was obtained by gene trap method and may be only be a hypomorphic allele (Long et al, 2004;Fouquet et al, 2007). Accordingly, their telencephalon has a milder phenotype than another line obtained by classic gene targeting method (Andrews et al, 2006;Lopez-Bendito et al, 2007).…”

Section: Discussionmentioning

confidence: 98%

“…Slit/Robo signaling controls midline crossing by a variety of axons (Dickson, 2002;Fouquet et al, 2007). In Drosophila, Slit/ Robo signaling also prevents tracheal, sensory precursor cells, and cardiac cells from approaching the midline (Lundstrom et al, 2004;Orgogozo et al, 2004;Santiago-Martinez et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…Swiss mice (Janvier) were used for expression studies. Slit-deficient mice and Robo-deficient mice (all in C57BL/6 inbred strain) were described previously and genotyped by PCR (Plump et al, 2002;Grieshammer et al, 2004;Long et al, 2004;Sabatier et al, 2004;Fouquet et al, 2007). The day of the vaginal plug was counted as embryonic day 0 (E0), and the day of the birth as postnatal day 0 (P0).…”

Section: Methodsmentioning

confidence: 99%

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Molecular Mechanisms Controlling Midline Crossing by Precerebellar Neurons

Meglio¹,

Nguyen-Ba-Charvet²,

Tessier‐Lavigne³

et al. 2008

Journal of Neuroscience

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Precerebellar neurons of the inferior olive (IO) and lateral reticular nucleus (LRN) migrate tangentially from the rhombic lip toward the floor plate following parallel pathways. This process is thought to involve netrin-1 attraction. However, whereas the cell bodies of LRN neurons cross the midline, IO neurons are unable to do so. In many systems and species, axon guidance and cell migration at the midline are controlled by Slits and their receptor Robos. We showed previously that precerebellar axons and neurons do not cross the midline in the absence of the Robo3 receptor. To determine whether this signaling by Slits and the two other Robo receptors, Robo1 and Robo2, also regulates precerebellar neuron behavior at the floor plate, we studied the phenotype of Slit1/2 and Robo1/2/3 compound mutants. Our results showed that many IO neurons can cross the midline in absence of Slit1/2 or Robo1/2, supporting a role for midline repellents in guiding precerebellar neurons. We also show that these molecules control the development of the lamellation of the inferior olivary complex. Last, the analysis of Robo1/2/3 triple mutants suggests that Robo3 inhibits Robo1/2 repulsion in precrossing LRN axons but not in IO axons in which it has a dominant and distinct function.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Molecular Mechanisms Controlling Midline Crossing by Precerebellar Neurons

Meglio¹,

Nguyen-Ba-Charvet²,

Tessier‐Lavigne³

et al. 2008

Journal of Neuroscience

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“…It was shown that LOT axons follow a path that is delineated by a specific set of cells, called the LOT cells. It was initially thought that the LOT cells were acting as guidepost cells for LOT axons, but these can be misguided even if the LOT cells are properly positioned, suggesting that these are not sufficient for guiding LOT axons (Fouquet et al 2007). Cell-labeling studies showed that LOT cells are among the first to be born in the dorsal telencephalon and that they migrate tangentially (between E9.5 and E11.5 in the mouse) in a ventral direction to their final position at the surface of the forebrain (Tomioka et al 2000;Kawasaki et al 2006).…”

Section: Semaphorin Function In the Tangential Migration Of Cortical mentioning

confidence: 99%

Semaphorins and Cell Migration in the Central Nervous System

Chédotal

2015

Semaphorins

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In the central nervous system (CNS), neuroblasts, postmitotic neurons, and glial cells migrate along stereotyped routes from their birthplace to their final destination. Two main types of neuronal migration have been distinguished: a radial one for neurons that migrate along radial glia in a direction perpendicular to the pial surface and a tangential mode for neurons which migrate along other neurons or axons, independently of radial glia (Marin O, Rubenstein JL, Annu Rev Neurosci 26: 441-483, 2003; Metin et al, J Neurosci 28(46):11746-11752, 2008). The initiation of migration, the direction followed by migrating neurons or glia, and their decision at specific choice points are influenced by molecules in the environment of the neurons and by intrinsic developmental programs. Many studies in various systems have shown that semaphorins and their receptors play an essential role in this process. Semaphorins influence the motility of neurons and oligodendrocytes and also shape the pathway they follow during their migration. Here, I review these results, focusing on the vertebrate CNS and a few model systems. Keywords Neural stem cells • Cerebellum • Granule cells • Centrosome • Oligodendrocytes • GnRH Semaphorins Control the Radial Migration of Cortical NeuronsThe six-layered mammalian neocortex contains two main types of neurons: (1) pyramidal neurons that primarily project outside the cortex and originate from the ventricular zone of the dorsal telencephalon, or pallium; and (2) interneurons, which make local connections between different layers or across layers and originate from the ganglionic eminence in the ventral telencephalon or subpallium (Rakic 2009; A. Chédotal ( )

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“…The migration of these cells is directed by Netrin and Sema3F (Kawasaki et al 2006;Ito et al 2008) and the development of the LOT axons depends on the presence of these cells. Slits secreted from the septum, and several secreted semaphorins, also play a key role in LOT positioning (de Castro et al 1999;Nguyen Ba-Charvet et al 1999;Nguyen-Ba-Charvet et al 2002;Fouquet et al 2007). In the telencephalon, several other migratory populations of neurons are implicated in axon guidance.…”

Section: Mechanisms Of Axon Guidance In the Brainmentioning

confidence: 99%

Wiring the Brain: The Biology of Neuronal Guidance

Chédotal

Richards

2010

Cold Spring Harbor Perspectives in Biology

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138

106

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The mammalian brain is the most complex organ in the body. It controls all aspects of our bodily functions and interprets the world around us through our senses. It defines us as human beings through our memories and our ability to plan for the future. Crucial to all these functions is how the brain is wired in order to perform these tasks. The basic map of brain wiring occurs during embryonic and postnatal development through a series of precisely orchestrated developmental events regulated by specific molecular mechanisms. Below we review the most important features of mammalian brain wiring derived from work in both mammals and in nonmammalian species. These mechanisms are highly conserved throughout evolution, simply becoming more complex in the mammalian brain. This fascinating area of biology is uncovering the essence of what makes the mammalian brain able to perform the everyday tasks we take for granted, as well as those which give us the ability for extraordinary achievement. PATTERNING OF THE BRAIN IN RELATION TO PIONEERING AXONS

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Robo1 and Robo2 Control the Development of the Lateral Olfactory Tract

Cited by 47 publications

References 59 publications

Molecular Mechanisms Controlling Midline Crossing by Precerebellar Neurons

Molecular Mechanisms Controlling Midline Crossing by Precerebellar Neurons

Semaphorins and Cell Migration in the Central Nervous System

Wiring the Brain: The Biology of Neuronal Guidance

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