Robo-Therm, a pipeline to RNA Thermometer discovery and validation
Davis M Sharts,
Maria T. Almanza,
Andrea Victoria Banks
et al.
Abstract:RNA thermometers are highly structured noncoding RNAs located in the 5′ untranslated regions (UTR) of genes that regulate expression by undergoing conformational changes in response to temperature. The discovery of RNA thermometers through bioinformatics is difficult because there is little sequence conservation among their structural elements. Thus, the abundance of these thermo-sensitive regulatory structures remains unclear. Herein, to advance the discovery and validation of RNA thermometers, we developed R… Show more
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