Robertsonian heterozygosity in wild mice: fertility and transmission rates in Rb(16.17) translocation heterozygotes

Britton‐Davidian, Janice; Sonjaya, Herry; Catalan, Josette; Cattaneo-Berrebi, G.

doi:10.1007/bf00137322

Cited by 47 publications

(34 citation statements)

References 17 publications

(13 reference statements)

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“…Meiotic pairing between homologues that differ by a Robertsonian rearrangement (i.e., pairing between a metacentric chromosome and the two acrocentric homologues) would produce a trivalent in the F 1 hybrids, which would not necessarily cause malsegregation and unbalanced gametes. For example, the rate of nondisjunction was not different in individuals that were heterozygous for Robertsonian rearrangements compared to homozygotes in pink salmon ( O. gorbuscha ) [40], house mouse ( Mus musculus domesticus ) [41], and Eurasian common shrew ( Sorex araneus ) [42], suggesting this type of rearrangement produces balanced gametes.…”

Section: Discussionmentioning

confidence: 99%

Chromosome rearrangements, recombination suppression, and limited segregation distortion in hybrids between Yellowstone cutthroat trout (Oncorhynchus clarkii bouvieri) and rainbow trout (O. mykiss)

et al. 2013

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BackgroundIntrogressive hybridization is an important evolutionary process that can lead to the creation of novel genome structures and thus potentially new genetic variation for selection to act upon. On the other hand, hybridization with introduced species can threaten native species, such as cutthroat trout (Oncorhynchus clarkii) following the introduction of rainbow trout (O. mykiss). Neither the evolutionary consequences nor conservation implications of rainbow trout introgression in cutthroat trout is well understood. Therefore, we generated a genetic linkage map for rainbow-Yellowstone cutthroat trout (O. clarkii bouvieri) hybrids to evaluate genome processes that may help explain how introgression affects hybrid genome evolution.ResultsThe hybrid map closely aligned with the rainbow trout map (a cutthroat trout map does not exist), sharing all but one linkage group. This linkage group (RYHyb20) represented a fusion between an acrocentric (Omy28) and a metacentric chromosome (Omy20) in rainbow trout. Additional mapping in Yellowstone cutthroat trout indicated the two rainbow trout homologues were fused in the Yellowstone genome. Variation in the number of hybrid linkage groups (28 or 29) likely depended on a Robertsonian rearrangement polymorphism within the rainbow trout stock. Comparison between the female-merged F1 map and a female consensus rainbow trout map revealed that introgression suppressed recombination across large genomic regions in 5 hybrid linkage groups. Two of these linkage groups (RYHyb20 and RYHyb25_29) contained confirmed chromosome rearrangements between rainbow and Yellowstone cutthroat trout indicating that rearrangements may suppress recombination. The frequency of allelic and genotypic segregation distortion varied among parents and families, suggesting few incompatibilities exist between rainbow and Yellowstone cutthroat trout genomes.ConclusionsChromosome rearrangements suppressed recombination in the hybrids. This result supports several previous findings demonstrating that recombination suppression restricts gene flow between chromosomes that differ by arrangement. Conservation of synteny and map order between the hybrid and rainbow trout maps and minimal segregation distortion in the hybrids suggest rainbow and Yellowstone cutthroat trout genomes freely introgress across chromosomes with similar arrangement. Taken together, these results suggest that rearrangements impede introgression. Recombination suppression across rearrangements could enable large portions of non-recombined chromosomes to persist within admixed populations.

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Section: Discussionmentioning

confidence: 99%

Chromosome rearrangements, recombination suppression, and limited segregation distortion in hybrids between Yellowstone cutthroat trout (Oncorhynchus clarkii bouvieri) and rainbow trout (O. mykiss)

et al. 2013

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“…Extensive studies in house mice heterozygous for Robertsonian translocations detected a decrease of fertility in the heterozygotes depending on the number and complexity of meiotic configurations. Simple Robertsonian heterozygotes for 1-3 rearrangements usually had normal fertility (Winking et al 1988;Britton-Davidian et al 1990;Wallace et al 1992), whereas mice producing many trivalents or long chains or rings during meiosis had low fertility and some of them were sterile (Gropp and Winking 1981;Said et al 1993;Hauffe and Searle 1998).…”

Section: Genetic Versus Chromosomal Cause Of Hybrid Sterilitymentioning

confidence: 97%

Reproductive isolation due to the genetic incompatibilities betweenThrichomys pachyurusand two subspecies ofThrichomys apereoides(Rodentia, Echimyidae)

Бородин¹,

Barreiros-Gómez²,

Zhelezova³

et al. 2006

Genome

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We tested intrinsic reproductive isolation between 3 taxa of the South American caviomorph rodent Thrichomys (Rodentia, Echimyidae): T. pachyurus, T. apereoides subsp. apereoides and T. apereoides subsp. laurentius. They were mated in captivity and produced viable progeny. Some F1 hybrid females were fertile, whereas all F1 males were sterile. Histological examination revealed meiotic arrest at the primary spermatocyte stage. No sperm was detected in testes or epididymes. Electron microscopic analysis of surface spread synaptonemal complexes revealed a complete failure of chromosome pairing in F1 hybrids of T. pachyurus with T. apereoides subsp. laurentius and T. apereoides subsp. apereoides. In the male hybrids between T. apereoides subsp. apereoides and T. apereoides subsp. laurentius, meiosis did not proceed beyond diplotene, although all of the chromosomes, including heteromorphic ones, paired in an orderly fashion. Backcross males with homomorphic karyotypes showed segregation in meiosis progression. This indicates that male hybrid sterility is due to genetic, but not chromosomal, incompatibility of the parental taxa.

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“…They may, therefore, act as postmating isolating mechanisms. To date, two major conclusions can be drawn from the research on fertility of Rb mice: 1) reduction in fertility is more severe in complex heterozygotes characterized by one or more metacentrics with monobrachial arm homology than in simple heterozygotes characterized by one or multiple heterozygotes each one complemented by its homologous telocentrics (Redi & Capanna 1988, Hauffe & Searle 1998; 2) simple heterozygotes have a significant reduction in fertility associated with the presence of seven to nine heterozygous Rb fusions (Hauffe & Searle 1998, Castiglia & Capanna 2000, Wallace et al 2002, Merico et al 2003, Manterola et al 2009), while when the number Rb fusions is low (from 1 to 3), less important alterations in reproduction have been detected (Britton-Davidian et al 1990, Wallace et al 1992, Hauffe & Searle 1998, Wallace 2003. These conclusions are based mainly on a number of analyses of meiotic non-disjunction of multivalents in structural heterozygotes (e.g.…”

Section: Introductionmentioning

confidence: 99%

Spermatogenesis in house mouse in a Robertsonian polymorphism zone

Sans-Fuentes¹,

García‐Valero²,

Ventura³

et al. 2010

Reproduction

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Robertsonian (Rb) translocations can be important in speciation as a mechanism of postzygotic isolation between populations. Meiotic non-disjunction, gametogenic impairment, and association of impaired autosomal segments with sex chromosomes have been postulated as mechanisms responsible for reducing fertility in Rb mice. Quantitative histological studies needed to understand the role of Rb fusions in gametogenic impairment are scarce. Most research on Rb mice has analyzed meiotic non-disjunction of laboratory and wild-derived strains, which have complex or simple structural heterozygosity with large numbers of fusions. Using histological multilevel sampling, we examined spermatogenesis in mice from the Rb polymorphism area of Barcelona. We studied four chromosomal groups having: a) one Rb heterozygote fusion and 2nZ39, b) one Rb heterozygote fusion and 2nZ31, c) three Rb heterozygote fusions without monobrachial homology and with diploid number ranging from 2nZ29 to 2nZ37, and d) only Rb homozygote fusions with diploid number ranging from 2nZ28 to 2nZ30. Standard mice from the area surrounding the Rb zone were used as control. We analyzed morphological variables of the testes, relative frequency of stages in the seminiferous epithelium cycle, the 'round spermatids:primary spermatocytes' ratio, and other derived parameters. Our results reveal that structural homozygote mice and simple heterozygote mice having as few as one to three Rb fusions undergo greater germ cell death (GCD) than standard mice, suggesting that Rb fusions are related to increased GCD (in both the heterozygous and homozygous state) and may be the main cause of decreased gene flow between mice populations from this area.

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Robertsonian heterozygosity in wild mice: fertility and transmission rates in Rb(16.17) translocation heterozygotes

Cited by 47 publications

References 17 publications

Chromosome rearrangements, recombination suppression, and limited segregation distortion in hybrids between Yellowstone cutthroat trout (Oncorhynchus clarkii bouvieri) and rainbow trout (O. mykiss)

Chromosome rearrangements, recombination suppression, and limited segregation distortion in hybrids between Yellowstone cutthroat trout (Oncorhynchus clarkii bouvieri) and rainbow trout (O. mykiss)

Reproductive isolation due to the genetic incompatibilities betweenThrichomys pachyurusand two subspecies ofThrichomys apereoides(Rodentia, Echimyidae)

Spermatogenesis in house mouse in a Robertsonian polymorphism zone

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