Robbins and Cotran Pathologic Basis of Disease: 7th Edition

Tseung, Jason

doi:10.1080/00313020500059191

Cited by 23 publications

(22 citation statements)

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“…Migration of monocytes into the sub-intimal territory and subsequent “consumption” of lipoproteins gives rise to foam cells, which collectively contribute to the “fatty streak” within the intimal layer of the arterial wall. Inflammatory mediators and smooth muscle cells migrate from into the intima to promote formation of an atheromatous plaque [3]…”

Section: Physiology Of Atherogenesis and Thrombosismentioning

confidence: 99%

“…This process is followed by secondary hemostasis, which involves progression through a coagulation cascade to generate cross linked fibrin products. Disruption of atheromatous plaques formed within arterial walls causes exposure of thrombogenic material and rapid formation of thrombus, which in turn increases the size of the intimal plaque and causes hemodynamically significant occlusion of the effective luminal area [3].…”

Section: Physiology Of Atherogenesis and Thrombosismentioning

confidence: 99%

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Environmental Tobacco Smoke and Cardiovascular Disease

DiGiacomo

Jazayeri

Barua

et al. 2018

IJERPH

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Environmental tobacco smoke (ETS) and its sequelae are among the largest economic and healthcare burdens in the United States and worldwide. The relationship between active smoking and atherosclerosis is well-described in the literature. However, the specific mechanisms by which ETS influences atherosclerosis are incompletely understood. In this paper, we highlight the definition and chemical constituents of ETS, review the existing literature outlining the effects of ETS on atherogenesis and thrombosis in both animal and human models, and briefly outline the public health implications of ETS based on these data.

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Section: Physiology Of Atherogenesis and Thrombosismentioning

confidence: 99%

Section: Physiology Of Atherogenesis and Thrombosismentioning

confidence: 99%

Environmental Tobacco Smoke and Cardiovascular Disease

DiGiacomo

Jazayeri

Barua

et al. 2018

IJERPH

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“…A major feature of the disease is the inability of an individual’s insulin to maintain normoglycemia. Major consequences occurring due to reduced insulin sensitivity by tissues for which glycemic balance is particularly important, such as adipose tissue muscles, liver, may be very severe [ 1 , 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Insulin-Sensitizer Effects of Fenugreek Seeds in Parallel with Changes in Plasma MCH Levels in Healthy Volunteers

Kiss

Szabó

Gesztelyi

et al. 2018

IJMS

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In developed, developing and low-income countries alike, type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases, the severity of which is substantially a consequence of multiple organ complications that occur due to long-term progression of the disease before diagnosis and treatment. Despite enormous investment into the characterization of the disease, its long-term management remains problematic, with those afflicted enduring significant degradation in quality-of-life. Current research efforts into the etiology and pathogenesis of T2DM, are focused on defining aberrations in cellular physiology that result in development of insulin resistance and strategies for increasing insulin sensitivity, along with downstream effects on T2DM pathogenesis. Ongoing use of plant-derived naturally occurring materials to delay the onset of the disease or alleviate symptoms is viewed by clinicians as particularly desirable due to well-established efficacy and minimal toxicity of such preparations, along with generally lower per-patient costs, in comparison to many modern pharmaceuticals. A particularly attractive candidate in this respect, is fenugreek, a plant that has been used as a flavouring in human diet through recorded history. The present study assessed the insulin-sensitizing effect of fenugreek seeds in a cohort of human volunteers, and tested a hypothesis that melanin-concentrating hormone (MCH) acts as a critical determinant of this effect. A test of the hypothesis was undertaken using a hyperinsulinemic euglycemic glucose clamp approach to assess insulin sensitivity in response to oral administration of a fenugreek seed preparation to healthy subjects. Outcomes of these evaluations demonstrated significant improvement in glucose tolerance, especially in patients with impaired glucose responses. Outcome data further suggested that fenugreek seed intake-mediated improvement in insulin sensitivity correlated with reduction in MCH levels.

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“…musculares lisas dentro de la íntima y se produce además una síntesis y depósito de matriz extracelular (34) . Las células endoteliales pueden responder a diversos estímulos anormales (35) , como son los inducidos por histamina, serotonina y otros mediadores vasoactivos que producen un aumento en la permeabilidad, inhiben la liberación de óxido nítrico y redistribuyen la glicoproteína de adhesión. Estos estímulos endoteliales suponen respuestas reversibles rápidas.…”

Section: El Sistema Circulatoriounclassified

“…y muscular (dcha.) de(25) ...................... Mecanismo de migración célula muscular, proliferación de matriz extracelular y engrosamiento intimal, de(35 ....................................................................................................Detalle de un catéter con balón de Fogarty inflado .................................................... Tipos de daños arteriales por catéter de Fogarty: Perforación arterial, ruptura arterial y daños en la íntima. Modificado de (83)Foster1970, pág 973 .................................... Figura 11 Internal Vessel Occluder, modificado de: http://www.synovissurgical.com/flo_rester_internal_vessel_occluder.php ........................... Distintos tipos de clamps vasculares, A: Pinza DeBackey, B: Clamp vascular Satinsky, C: Clamp vascular Cooley, D: Bulldog vascular DeBackey, modificado de (110) ......................... Detalle de anastomosis vasculares microquirúgicas con dos clamps vasculares dobles.…”

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Valoración del daño parietal a nivel vascular, tras la aplicación de métodos extraluminales de oclusión temporal

Barcia¹

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Oclusión vascular y daño histológico 82 Sangre completa 64.1 (57.5-69.9) ml/kg Frecuencia respiratoria 85.5 (66-114)/min Volumen tidal 0.86 (0.60-1.25) ml Volumen minuto 0.073 (0.05-0.101) ml Volumen de eyección 1.3-2.0 ml/latido. Tabla 7: Parámetros cardiorespiratorios de la rata, modificado de (130, 131, 133-135) Peso adulto: Macho 300-400 gr. Hembra 250-300 gr. Esperanza de vida: Usual 2.5-3 años Máxima 4 años y 8 meses Área superficie 0.03-0.06 cm2 Número de cromosomas 42 Consumo de agua 80-110 ml/kg/dia Consumo de comida 100 gr/kg/dia

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Robbins and Cotran Pathologic Basis of Disease: 7th Edition

Cited by 23 publications

References 0 publications

Environmental Tobacco Smoke and Cardiovascular Disease

Environmental Tobacco Smoke and Cardiovascular Disease

Insulin-Sensitizer Effects of Fenugreek Seeds in Parallel with Changes in Plasma MCH Levels in Healthy Volunteers

Valoración del daño parietal a nivel vascular, tras la aplicación de métodos extraluminales de oclusión temporal

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