Roadmap on bio-nano-photonics

Herkert, Ediz; Slesiona, Nicole; Recchia, Martina; Deckert, Thomas; García-Parajo, María F.; Fantuzzi, Eric Michele; Pruccoli, Andrea; Ragupathy, Imaiyan Chitra; Gudavičius, Dominykas; Rigneault, Hervé; Majer, Jan; Zumbusch, Andreas; Munger, Eleanor B.; Brasselet, Sophie; Jones, Arwyn Tomos; Watson, Peter; Boppart, Stephen A.; Singh, Vikramdeep; Borkar, Saurabh; Rodriguez, Frank Ernesto Quintela; Langbein, Wolfgang Werner; Petropoulos, Vasilis; Hulst, N.F. van; Maiuri, Margherita; Cerullo, Giulio; Brida, Daniele; Troiani, Filippo; Rozzi, Carlo Andrea; Molinari, Elisa; Vengris, Mikas; Borri, Paola

doi:10.1088/2040-8986/abff94

Cited by 6 publications

(7 citation statements)

References 161 publications

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“…However, the light induced polarization can be expressed as a power series in the electric field in the nonlinear optics, in which χ (1) is the linear susceptibility, while χ (2) and χ (3) are the second-and third-order nonlinear optical susceptibilities of the material, respectively [183,185]. Recently, nonlinear optical materials have attracted tremendous interest in a wide range of applications, such as photonics, nano-photonics, bio-photonics, and quantum photonics [186,187]. Interestingly, most ferroelectrics also possess a large nonlinear response with respect to the electromagnetic radiation in the optical range [188][189][190].…”

Section: Nonlinear Optical Propertiesmentioning

confidence: 99%

Dawn of nitride ferroelectric semiconductors: from materials to devices

Wang

Mondal

et al. 2023

Semicond. Sci. Technol.

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III-nitride semiconductors are promising optoelectronic and electronic materials and have been extensively investigated in the past decades. New functionalities, such as ferroelectricity, ferromagnetism, and superconductivity, have been implanted into III-nitrides to expand their capability in next-generation semiconductor and quantum technologies. The recent experimental demonstration of ferroelectricity in nitride materials, including ScAl(Ga)N, BAlN, and hBN, has inspired tremendous research interest. Due to the large remnant polarization, high breakdown field, high Curie temperature, and significantly enhanced piezoelectric, linear, and nonlinear optical properties, nitride ferroelectric semiconductors have enabled a wealth of applications in electronic, ferroelectronic, acoustoelectronic, optoelectronic, and quantum devices and systems. In this review, the development of nitride ferroelectric semiconductors from materials to devices is discussed. While expounding on the unique advantages and outstanding achievements of nitride ferroelectrics, the existing challenges and promising prospects have been also discussed.

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Section: Nonlinear Optical Propertiesmentioning

confidence: 99%

Dawn of nitride ferroelectric semiconductors: from materials to devices

Wang

Mondal

et al. 2023

Semicond. Sci. Technol.

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“…[8][9][10][11][12] Such imaging modalities provide distinct advantages: they are less prone to bleaching than fluorescence, they are not associated with molecular energy levels thus allowing flexible excitation/detection wavelengths for deeper penetration, and their emission is spectrally narrower. With the recent availability of compact light sources based on optical parametric oscillators (OPO) or amplifiers (OPA), [13] properties of nonlinear parametric signals can now be utilized in the short-wave infrared (SWIR) spectral range, leading to increased penetration depth [14,15] and mitigating autofluorescence. Importantly, the quasi-instantaneous response of parametric signals, so far rarely exploited, is compatible with extreme imaging speed characterized by dwell times approaching or shorter than typical fluorescence lifetimes (nanoseconds).…”

Section: Introductionmentioning

confidence: 99%

Harmonic Imaging of Stem Cells in Whole Blood at GHz Pixel Rate

Karpf,

Glöckner Burmeister,

Dubreil

et al. 2024

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The pre‐clinical validation of cell therapies requires monitoring the biodistribution of transplanted cells in tissues of host organisms. Real‐time detection of these cells in the circulatory system and identification of their aggregation state is a crucial piece of information, but necessitates deep penetration and fast imaging with high selectivity, subcellular resolution, and high throughput. In this study, multiphoton‐based in‐flow detection of human stem cells in whole, unfiltered blood is demonstrated in a microfluidic channel. The approach relies on a multiphoton microscope with diffractive scanning in the direction perpendicular to the flow via a rapidly wavelength‐swept laser. Stem cells are labeled with metal oxide harmonic nanoparticles. Thanks to their strong and quasi‐instantaneous second harmonic generation (SHG), an imaging rate in excess of 10 000 frames per second is achieved with pixel dwell times of 1 ns, a duration shorter than typical fluorescence lifetimes yet compatible with SHG. Through automated cell identification and segmentation, morphological features of each individual detected event are extracted and cell aggregates are distinguished from isolated cells. This combination of high‐speed multiphoton microscopy and high‐sensitivity SHG nanoparticle labeling in turbid media promises the detection of rare cells in the bloodstream for assessing novel cell‐based therapies.

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“…Nanophotonic biosensors based on metallic nanostructures have gained popularity in recent years, as they are capable of confining and enhancing light in subdiffraction volumes through the excitation of plasmonic resonances. − The confined high-intensity observation volumes provided by the nanostructures enable pushing the concentration limit toward the physiologically relevant regime and thus observing individual target molecules in their native environment. Metallic nanostructures can manipulate not only the excitation of a molecule by confining and enhancing the excitation field but also its emission by modifying the quantum yield. , The latter originates from two competing processes introduced by the nanostructures.…”

mentioning

confidence: 99%

“…Besides their superior performance, such optimized hybrid material devices could become particularly relevant in multicolor fluorescence applications which are so far limited to the red and near-infrared spectral range in gold-based nanostructures . Moreover, surface-enhanced vibrational spectroscopy could largely benefit from the high intensity enhancement provided by the AiB platforms due to the very low Raman scattering cross sections. ,− …”

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confidence: 99%

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Hybrid Plasmonic Nanostructures for Enhanced Single-Molecule Detection Sensitivity

et al. 2023

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Biosensing applications based on fluorescence detection often require single-molecule sensitivity in the presence of strong background signals. Plasmonic nanoantennas are particularly suitable for these tasks, as they can confine and enhance light in volumes far below the diffraction limit. The recently introduced antenna-in-box (AiB) platforms achieved high single-molecule detection sensitivity at high fluorophore concentrations by placing gold nanoantennas in a gold aperture. However, hybrid AiB platforms with alternative aperture materials such as aluminum promise superior performance by providing better background screening. Here, we report on the fabrication and optical characterization of hybrid AiBs made of gold and aluminum for enhanced single-molecule detection sensitivity. We computationally optimize the optical properties of AiBs by controlling their geometry and materials and find that hybrid nanostructures not only improve signal-to-background ratios but also provide additional excitation intensity and fluorescence enhancements. We further establish a two-step electron beam lithography process to fabricate hybrid material AiB arrays with high reproducibility and experimentally validate the higher excitation and emission enhancements of the hybrid nanostructures as compared to their gold counterpart. We foresee that biosensors based on hybrid AiBs will provide improved sensitivity beyond the capabilities of current nanophotonic sensors for a plethora of biosensing applications ranging from multicolor fluorescence detection to label-free vibrational spectroscopy.

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Roadmap on bio-nano-photonics

Cited by 6 publications

References 161 publications

Dawn of nitride ferroelectric semiconductors: from materials to devices

Dawn of nitride ferroelectric semiconductors: from materials to devices

Harmonic Imaging of Stem Cells in Whole Blood at GHz Pixel Rate

Hybrid Plasmonic Nanostructures for Enhanced Single-Molecule Detection Sensitivity

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