Road map to the treatment of neglected tropical diseases: Nanocarriers interventions

Joshi, Garima; Quadir, Sheikh Shahnawaz; Yadav, Khushwant S.

doi:10.1016/j.jconrel.2021.09.020

Cited by 22 publications

(15 citation statements)

References 124 publications

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“…These drugs, though highly effective against leprosy, are classified as Class II drugs according to the Biopharmaceutics Classification System as they have low water solubility and oral drug bioavailability [ 94 ]. Clofazimine tends to re-crystallize in cells and intestinal lumen due to the high dosage [ 95 ]. There are also incidences of antibiotic resistance cropping up due to such issues.…”

Section: Nanotechnology and Leprosymentioning

confidence: 99%

Impact of nanoparticles on amyloid β-induced Alzheimer’s disease, tuberculosis, leprosy and cancer: a systematic review

et al. 2023

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Nanotechnology is an interdisciplinary domain of science, technology and engineering that deals with nano-sized materials/particles. Usually, the size of nanoparticles lies between 1-100 nm. Due to their small size and large surface area-to-volume ratio, nanoparticles exhibit high reactivity, greater stability and adsorption capacity. These important physicochemical properties attract scientific community to utilize them in biomedical field. Various types of nanoparticles (inorganic and organic) have broad applications in medical field ranging from imaging to gene therapy. These are also effective drug carriers. In recent times, nanoparticles are utilized to circumvent different treatment limitations. For example, the ability of nanoparticles to cross the blood brain barrier and having a certain degree of specificity towards amyloid deposits, makes themselves important candidates for the treatment of Alzheimer’s disease. Furthermore, nanotechnology has been used extensively to overcome several pertinent issues like drug-resistance phenomenon, side effects of conventional drugs and targeted drug delivery issue in leprosy, tuberculosis and cancer. Thus, in this review, the application of different nanoparticles for the treatment of these four important diseases (Alzheimer’s disease, tuberculosis, leprosy and cancer) as well as for the effective delivery of drugs used in these diseases has been presented systematically. Although nanoformulations have many advantages over traditional therapeutics for treating these diseases, nanotoxicity is a major concern which has been discussed subsequently. Lastly, we have presented the promising future prospective of nanoparticles as alternative therapeutics. In that section, we have discussed about the futuristic approach(es) that could provide promising candidate(s) for the treatment of these four diseases.

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Section: Nanotechnology and Leprosymentioning

confidence: 99%

Impact of nanoparticles on amyloid β-induced Alzheimer’s disease, tuberculosis, leprosy and cancer: a systematic review

et al. 2023

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“…This trend is slowly changing with larger participation from the government to aid in NTD research. 10 We hope that future days will show more effort and awareness toward a better solution.…”

Section: Challenges In Studying Ntdmentioning

confidence: 99%

Neglected tropical disease: Why we need to prioritize them more

2022

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Neglected tropical diseases (NTDs) are those that are commonly found in several low-income countries in Africa, Asia, and Latin America and where people do not have access to hygiene, clean water, or safe ways to dispose of human waste. NTDs comprise a diverse group of diseases that is highly prevalent in tropical countries and is caused by a variety of pathogens, including bacteria viruses, parasites, and fungi. Although there are debates on what is included under NTD, few that are listed are ascariasis, Buruli ulcer, Chagas disease, dracunculiasis, hookworm infection, human African trypanosomiasis, Leishmaniasis, leprosy, lymphatic filariasis (LF), onchocerciasis, schistosomiasis, trachoma, and trichuriasis, though this list. keeps on changing. They are called “neglected,” because they are hardly represented in the global health agenda of the developed countries and are often associated with stigma, blind faith, and social exclusion. The epidemiology of NTDs is quite complex and often related to environmental conditions. Many of them are vector-borne, have a zoonotic origin with well characterized animal reservoirs, and are associated with complex life cycles. All these factors make their public health control challenging. With a population of over 1.3 billion, India accounts for nearly one-half of the world’s prevalent cases of visceral leishmaniasis and one-half of the global incident cases of dengue, one-third, or more of the prevalent cases of leprosy, LF, cysticercosis, and visual impairment due to trachoma. India also accounts for 25% world’s burden of ascariasis and hookworm cases. Unfortunately in India, we don’t have a uniform distribution of neglected diseases. It was found to be very much dependent on the geographical locations as well as biased on the socialeconomic status, with more prevelant amongst the lower income groups. NTDs are not just any regular disease but were reported to cause permanent disabilities, impacting mental health and thereby posing a serious threat to livelihood and standard of living. Challenges in studying NTDThe primary challenge is adequate research funding and efforts. Affecting emerging economies, NTD severely suffers from the limelight that other lifestyle diseases such as cardiovascular, diabetes, and oncology enjoys. There was not much research output from the Western world too as NTD mostly affects the poorer nations. NTD related technologies are not considered profitable. This trend is slowly changing with larger participation from the government to aid in NTD research. We hope that future days will show more effort and awareness toward a better solution.

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“…A pesar de que las tecnologías relacionadas con las ETD no se consideran rentables, este escenario está cambiando lentamente con una mayor participación de algunos gobiernos para ayudar en la investigación de ETD (Joshi et al, 2021). En este contexto, la Organización Mundial de la Salud (OMS) y la Organización Panamericana de la Salud (OPS) se reúnen anualmente para unificar los protocolos de los ensayos clínicos y emitir sus recomendaciones para el tratamiento de tales enfermedades (Biomédica, 2018), algunas de las cuales pueden ser fácilmente prevenibles mediante la administración masiva de fármacos; lo que ha permitido lograr progresos en la reducción de su carga e incidencia en los últimos años.…”

Section: Las Enfermedades Tropicales Olvidadas O Desantendidas En Lat...unclassified

Experiencias suramericanas en telemedicina de enfermedades desatendidas

Salazar¹,

Macassi²,

Mejía³

et al. 2022

BMSA

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Las enfermedades tropicales desatendidas (ETD) son aquellas que comúnmente se encuentran en varios países de bajos ingresos en África, Asia y América Latina, provocadas básicamente, por el escaso acceso la higiene, agua limpia o sistemas de alcantarillado. Las ETD comprenden una diversidad de enfermedades de alta prevalencia en los países tropicales causadas por una variedad de patógenos, incluyendo bacterias, virus, parásitos y hongos. La epidemiología de las ETD es bastante compleja y se relacionan con las condiciones ambientales del entorno. Muchas son transmitidas por vectores, tienen un origen zoonótico con reservorios animales bien caracterizados y están asociadas con ciclos de vida complejos. Todos estos factores hacen que su control en salud pública sea un desafío; desafío que se caracteriza por la falta de financiamiento en investigación y control. En ese sentido, la telemedicina, o el uso de las telecomunicaciones para brindar servicios de salud, es una tecnología que ha venido ganando cuerpo durante los últimos veinte años, ya que ayudan, con una relativa baja inversión, el acceso a la atención médica por parte de los más necesitados o que vieven en lugares remotos. Esta investigación se centra en el estudio y conocimiento de las las enfermedades olvidadas presentes en suramérica y cómo la telemedicina ha ayudado en su prevención, diágnótico y tratamiento.

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Road map to the treatment of neglected tropical diseases: Nanocarriers interventions

Cited by 22 publications

References 124 publications

Impact of nanoparticles on amyloid β-induced Alzheimer’s disease, tuberculosis, leprosy and cancer: a systematic review

Impact of nanoparticles on amyloid β-induced Alzheimer’s disease, tuberculosis, leprosy and cancer: a systematic review

Neglected tropical disease: Why we need to prioritize them more

Experiencias suramericanas en telemedicina de enfermedades desatendidas

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