Rno_circ_0001004 Acts as a miR-709 Molecular Sponge to Regulate the Growth Hormone Synthesis and Cell Proliferation

Xiong, Jiali; Zhang, Haojie; Wang, Yuxuan; Cheng, Yi; Luo, Junyi; Chen, Ting; Xi, Qianyun; Sun, Jiajie; Zhang, Yongliang

doi:10.3390/ijms23031413

Cited by 6 publications

(4 citation statements)

References 53 publications

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“…Bioinformatics analysis of the ceRNA network further proved that the antiviral effect of miR-709 is related to CX3CR1. miR-709 also has the potential to target other genes and thus suppress JEV infection (Surendran et al, 2016;Xiong et al, 2022), an issue that requires further experimental verification.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain

Chen,

Kang,

Zhang

et al. 2024

Front. Microbiol.

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Japanese encephalitis is one of the most important insect-borne infectious disease with public health concern. The virus can break the blood–brain barrier and cause death or long-term sequela in infected humans or animals. Viral encephalitis is an important clinical feature of JEV infection. In recent studies, CircRNAs and related ceRNAs data illustrated the regulative role in many aspects of biological process and disease duration. It is believed that CircRNA regulates JEV infection in a ceRNA-dependent mechanism. In this study, brain tissues of experimental mice were sequenced and analysised. 61 differentially expressed circRNAs, 172 differentially expressed miRNAs and 706 differentially expressed mRNAs were identified by RNA-Sequencing and statistical analysis. CX3CR1 was determined as a key host factor impact JEV infection by microRNA interference measurement. CX3CR1 interaction network indicated circStrbp/miR709/CX3CR1 as a functional regulation axis. Further sequencing in BV2 cell shown CX3CR1 is a special target of miR-709 only during JEV infection. In summary, our study presented a new ceRNA pathway that impact JEV infection in vivo and in vitro, which could be a therapeutic target to fight against JEV.

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Section: Discussionmentioning

confidence: 99%

Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain

Chen,

Kang,

Zhang

et al. 2024

Front. Microbiol.

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“…CircRNAs are a special class of noncoding RNAs (ncRNAs) that, unlike linear RNAs, are covalently closed-loop structures produced by reverse splicing of pre-mRNAs ( Xiong et al, 2022 ). CircRNAs are highly stable and conserved across species because of their cyclization specificity ( Zhang et al, 2019 ), and circRNAs can interact with RNA-binding proteins to regulate gene expression ( Wang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis reveals pituitary lncRNA, circRNA and mRNA affecting fertility in high- and low-yielding goats

Mao,

Dong,

Hou

et al. 2023

Front. Genet.

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The pituitary gland serves as the central endocrine regulator of growth, reproduction, and metabolism and plays a crucial role in the reproductive process of female animals. Transcriptome analysis was conducted using pituitary gland samples from Leizhou goats with varying levels of fecundity to investigate the effects of long noncoding RNA (lncRNA), circular RNA (circRNA), and mRNA regulation on pituitary hormone secretion and its association with goat fecundity. The analysis aimed to identify lncRNAs, circRNAs, and mRNAs that influence the fertility of Leizhou goats. GO and KEGG enrichment analyses were performed on differentially expressed lncRNAs, circRNAs, and mRNAs and revealed considerable enrichment in pathways, such as regulation of hormone secretion, germ cell development, and gonadotropin-releasing hormone secretion. The pituitary lncRNAs (ENSCHIT00000010293, ENSCHIT00000010304, ENSCHIT00000010306, ENSCHIT00000010290, ENSCHIT00000010298, ENSCHIT00000006769, ENSCHIT00000006767, ENSCHIT00000006921, and ENSCHIT00000001330) and circRNAs (chicirc_029285, chicirc_026618, chicirc_129655, chicirc_018248, chicirc_122554, chicirc_087101, and chicirc_078945) identified as differentially expressed regulated hormone secretion in the pituitary through their respective host genes. Additionally, differential mRNAs (GABBR2, SYCP1, HNF4A, CBLN1, and CDKN1A) influenced goat fecundity by affecting hormone secretion in the pituitary gland. These findings contribute to the understanding of the molecular mechanisms underlying pituitary regulation of fecundity in Leizhou goats.

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“…Ribavirin was clinically used to treat infection with respiratory syncytial virus as well as other noninfluenza respiratory viruses (Gross and Bryson, 2015;Tejada et al, 2022). Ribavirin has also been used to treat patients infected with Lassa fever virus or Crimean-Congo hemorrhagic fever virus (Ascioglu et al, 2011;Johnson et al, 2018;Cheng et al, 2022). In particular, ribavirin had antiviral efficacy in children with tick-borne encephalitis (Skripchenko et al, 2019).…”

Section: Inhibition Of Tick-borne Encephalitis Virus In Cell Cultures...mentioning

confidence: 99%

Transmission and Infection of Arboviruses

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Rno_circ_0001004 Acts as a miR-709 Molecular Sponge to Regulate the Growth Hormone Synthesis and Cell Proliferation

Cited by 6 publications

References 53 publications

Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain

Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain

Transcriptome analysis reveals pituitary lncRNA, circRNA and mRNA affecting fertility in high- and low-yielding goats

Transmission and Infection of Arboviruses

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