In this chapter, a hardware processing architecture of real-time echo state network based on field-programmable gate array (FPGA) is proposed, which solves the problem that it is difficult to obtain the output weight of the network in real time. The design of this architecture strictly follows the reservoir calculation (RC) theory, and its five components are established in FPGA: input module, reservoir module, output module, training module, and system switch module. This paper implements the architecture in Altera FPGA chip and verifies it through the application of pattern recognition, waveform generation, and multiple-input multiple-output (MIMO) channel prediction. Experimental results show that the hardwareimplemented real-time echo state network can identify the duty cycle of different input signals, generate floating-point waveforms, and predict the MIMO channel by training. In this paper, a real-time echo state network based on field programmable gate array is proposed, which has the advantages of fast computation speed, less resource consumption, and ideal simple task execution.