Abstract:The failure of melanoma immunotherapy can be mediated by immunosuppression in the tumor microenvironment (TME) and insufficient activation effector T cells to against tumor. Here, we show that inhibition of galectin-3 (gal-3) enhances the infiltration of T cells in TME and improves the sensitivity of anti-PD-L1 therapy. We identify that RNF8 downregulated the expression of gal-3 by K48-polyubiquitination and promoted gal-3 degradation via ubiquitin proteasome system. RNF8 deficiency in host but sufficiency in … Show more
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