RNA Virus Reassortment: An Evolutionary Mechanism for Host Jumps and Immune Evasion

Vijaykrishna, Dhanasekaran; Mukerji, Reshmi; Smith, Gavin J. D.

doi:10.1371/journal.ppat.1004902

Cited by 115 publications

(93 citation statements)

References 51 publications

(61 reference statements)

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“…These exchanges have influenced fitness, transmission, and pathogenicity of the virus48. A recent study demonstrated that the reassortment of PB1, PB2, and HA of influenza B virus contributed to its fitness and replication49.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Circulation and Genetic Exchange of a Shrew-borne Hantavirus, Imjin virus, in the Republic of Korea

Lee

Kim

et al. 2017

Sci Rep

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Hantaviruses (family Bunyaviridae) are enveloped negative-sense tripartite RNA viruses. The natural hosts of hantaviruses include rodents, shrews, moles, and bats. Imjin virus (MJNV) is a shrew-borne hantavirus identified from the Ussuri white-toothed shrews (Crocidura lasiura) in the Republic of Korea (ROK) and China. We have isolated MJNV and determined its prevalence and molecular diversity in Gyeonggi province, ROK. However, the distribution and phylogeography of MJNV in other regions of ROK remain unknown. A total of 96 C. lasiura were captured from Gangwon and Gyeonggi provinces, ROK, during 2011–2014. Among them, four (4.2%) shrews were positive for anti-MJNV IgG and MJNV RNA was detected from nine (9.4%), respectively. Based on the prevalence of MJNV RNA, the preponderance of infected shrews was male and adult, consistent with the gender- and weight-specific prevalence of hantaviruses in other species. We monitored the viral load of MJNV RNA in various tissues of shrews, which would reflect the dynamic infectious status and circulation of MJNV in nature. Our phylogeographic and genomic characterization of MJNV suggested natural occurrences of recombination and reassortment in the virus population. Thus, these findings provide significant insights into the epidemiology, phylogeographic diversity, and dynamic circulation and evolution of shrew-borne hantaviruses.

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Section: Discussionmentioning

confidence: 99%

Dynamic Circulation and Genetic Exchange of a Shrew-borne Hantavirus, Imjin virus, in the Republic of Korea

Lee

Kim

et al. 2017

Sci Rep

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“…The segments bear different and complementary packaging signal sequences, which induce specific secondary RNA folding and a timely concerted interaction with the structural protein, ensuring the sorting of one copy of each segment per virion. Although such a precisely regulated process is highly efficient in phage Phi6 [64], it appears more variable in the case of Influenza virus , in which some studies reported virions with a complete set of segments [61,62] and others have evidenced virions with missing segments and/or duplicated ones [63,65]. A remarkable contrasting case is that of the Infectious bursal disease virus , with a genome made of two RNA segments but enough space in the virion to encapsidate up to four.…”

Section: Introductionmentioning

confidence: 99%

The Strange Lifestyle of Multipartite Viruses

et al. 2016

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Multipartite viruses have one of the most puzzling genetic organizations found in living organisms. These viruses have several genome segments, each containing only a part of the genetic information, and each individually encapsidated into a separate virus particle. While countless studies on molecular and cellular mechanisms of the infection cycle of multipartite viruses are available, just as for other virus types, very seldom is their lifestyle questioned at the viral system level. Moreover, the rare available “system” studies are purely theoretical, and their predictions on the putative benefit/cost balance of this peculiar genetic organization have not received experimental support. In light of ongoing progresses in general virology, we here challenge the current hypotheses explaining the evolutionary success of multipartite viruses and emphasize their shortcomings. We also discuss alternative ideas and research avenues to be explored in the future in order to solve the long-standing mystery of how viral systems composed of interdependent but physically separated information units can actually be functional.

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“…Even with extensive recombination, as observed among the "chromosomes" of influenza viruses, many viruses are known to jump from animals to humans [76,77], often leading to unusually severe outbreaks. The host environments do not vary as widely for viruses such as influenza A compared to arboviruses.…”

Section: How Are Protein-protein Interactions Related To Viruses Withmentioning

confidence: 99%

Protein-protein interactions of human viruses

Goodacre

Devkota

Bae

et al. 2020

Seminars in Cell & Developmental Biology

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Viruses infect their human hosts by a series of interactions between viral and host proteins, indicating that detailed knowledge of such virus-host interaction interfaces are critical for our understanding of viral infection mechanisms, disease etiology and the development of new drugs. In this review, we primarily survey human host-virus interaction data that are available from public databases following the standardized PSI-MS format. Notably, available host-virus protein interaction information is strongly biased toward a small number of virus families including herpesviridae, papillomaviridae, orthomyxoviridae and retroviridae. While we explore the reliability and relevance of these protein interactions we also survey the current knowledge about viruses functional and topological targets. Furthermore, we assess emerging frontiers of host-virus protein interaction research, focusing on protein interaction interfaces of hosts that are infected by different viruses and viruses that infect multiple hosts. Finally, we cover the current status of research that investigates the relationships of virus-targeted host proteins to other comorbidities as well as the influence of host-virus protein interactions on human metabolism.

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RNA Virus Reassortment: An Evolutionary Mechanism for Host Jumps and Immune Evasion

Cited by 115 publications

References 51 publications

Dynamic Circulation and Genetic Exchange of a Shrew-borne Hantavirus, Imjin virus, in the Republic of Korea

Dynamic Circulation and Genetic Exchange of a Shrew-borne Hantavirus, Imjin virus, in the Republic of Korea

The Strange Lifestyle of Multipartite Viruses

Protein-protein interactions of human viruses

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