RNA targeting by DNA binding drugs: Structural, conformational and energetic aspects of the binding of quinacrine and DAPI to A-form and HL-form of poly(rC)·poly(rG)

Biophysical studies on the base specificity and energetics of the DNA interaction of photoactive dye thionine: Spectroscopic and calorimetric approach

“…A large ΔCp value is usually associated with changes in hydrophobic or polar group hydration and considered as indicator of a dominant hydrophobic effect in the binding process. Negative heat capacity values have been observed for a variety of small molecules binding to DNA and RNA [21,23,27,35,42]. Change in solvent accessible surface area has been shown to be large component of ΔCp [44][45][46].…”

“…All the binding data were analyzed using Origin 7.0 software (Microcal Inc., Northampton, MA, USA) to determine the best-fit parameters of K i and 'n' as described in details earlier [24,27].…”

Toxic interaction of thionine to deoxyribonucleic acids: Elucidation of the sequence specificity of binding with polynucleotides

“…The binding data were analyzed using Origin 7.0 software (Microcal Inc., Northampton, MA, USA) as described previously [29,30,33] to give K i and n.…”

Inhibition of Encephalomyocarditis Virus and Poliovirus Replication by Quinacrine: Implications for the Design and Discovery of Novel Antiviral Drugs

“…Some properties of QC and 9AA that likely contribute to their biological activities have been identified. It has been well documented that both QC and 9AA can intercalate into double-stranded DNA and structured RNA molecules (31,34,44) and are capable of inhibiting DNA replication, RNA transcription, and protein synthesis (7,10,26,29). The extent of intercalation of QC into RNA molecules depends on the complexity of RNA secondary and tertiary structures (such as hairpin loops that produce regions of double-stranded RNA) and pseudoknots (2,52).…”