RNA-sequencing of Human Kidney Allografts and Delineation of T-Cell Genes, Gene Sets, and Pathways Associated With Acute T Cell–mediated Rejection
Franco B. Mueller,
Hua Yang,
Carol Li
et al.
Abstract:Background.
Delineation of T-cell genes, gene sets, pathways, and T-cell subtypes associated with acute T cell–mediated rejection (TCMR) may improve its management.
Methods.
We performed bulk RNA-sequencing of 34 kidney allograft biopsies (16 Banff TCMR and 18 no rejection [NR] biopsies) from 34 adult recipients of human kidneys. Computational analysis was performed to determine the differential intragraft expression of T-cell genes at the level of sing… Show more
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