2019
DOI: 10.3390/cancers12010064
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Abstract: Collecting duct carcinoma (CDC) is a rare renal cell carcinoma subtype with a very poor prognosis. There have been only a few studies on gene expression analysis in CDCs. We compared the gene expression profiles of two CDC cases with those of eight normal tissues of renal cell carcinoma patients. At a threshold of |log2fold-change| ≥1, 3349 genes were upregulated and 1947 genes were downregulated in CDCs compared to the normal samples. Pathway analysis of the deregulated genes revealed that cancer pathways and… Show more

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Cited by 11 publications
(11 citation statements)
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References 46 publications
(77 reference statements)
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“…Thus, our knowledge regarding potential ccRCC biomarkers for guiding intervention and surveillance has recently been dramatically expanded. Recent article by Wach et al reported the RNA sequencing of collecting duct carcinoma, a rare renal cell carcinoma subtype with a very poor prognosis and solute carrier (SLC) gene family (SLC3A1, SLC9A3, SLC26A7, and SLC47A1) was included in the most downregulated genes [24]. According to this study trend, our newly identified biomarkers may further aid in unraveling the evolutionary trajectories of ccRCC tumor growth.…”
Section: Discussionmentioning
confidence: 65%
“…Thus, our knowledge regarding potential ccRCC biomarkers for guiding intervention and surveillance has recently been dramatically expanded. Recent article by Wach et al reported the RNA sequencing of collecting duct carcinoma, a rare renal cell carcinoma subtype with a very poor prognosis and solute carrier (SLC) gene family (SLC3A1, SLC9A3, SLC26A7, and SLC47A1) was included in the most downregulated genes [24]. According to this study trend, our newly identified biomarkers may further aid in unraveling the evolutionary trajectories of ccRCC tumor growth.…”
Section: Discussionmentioning
confidence: 65%
“…RNA sequencing (RNA‐seq) is a useful tool to study the transcriptome. It can be used as an alternative to microarrays for gene expression analysis, without prior knowledge of the RNA sequence 5,6 . RNA‐seq provides more accurate data and applications in identifying differently expressed genes between pathological and control samples.…”
Section: Introductionmentioning
confidence: 99%
“…From the perspective of posttranscriptional modification, accumulating evidence demonstrates that SLC7A11 mRNA is derepressed by decreased miR-26b in human breast cancer and miR-375 in oral squamous cell carcinoma (34)(35)(36). And bioinformatic analysis predicted that SLC7A11 is targeted by different miRNAs, including has-mir-373 and has-mir-372 (37), miR-374b-5p and miR-26b-5p (38), and miRNA-126-3p/5p (39), but whether and how these miRNAs regulate SLC7A11 are not clear. In the present study, we predicted the candidate target genes for miR-27a-3p using TargetSan, miRanda, microT, PITA, miRmap, and PicTar platform.…”
Section: Mir-27a-3p Regulates Erastin Induced Ferroptosis In Nsclc Cellsmentioning
confidence: 99%