RNA-Seq analysis of long non-coding RNA in human intestinal epithelial cells infected by Shiga toxin-producing Escherichia coli

Zhang, Liuqing; Ma, Xuelian; Tong, Panpan; Zheng, Baili; Zhu, Mingyue; Peng, Bin; Wang, Jinquan; Liu, Yingyu

doi:10.1016/j.cyto.2023.156421

Cited by 2 publications

(1 citation statement)

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“…Escherichia coli ( E. coli ), among the most prevalent bacteria in nature, poses an urgent threat to human and animal health, with infections affecting the intestines, urinary tract, blood, and brain. In intestinal infections, research has highlighted that Shiga toxin-producing E. coli infections result in the differential expression of 702 lncRNAs within human intestinal epithelial cells [ 47 , 48 ]. Specifically, the F18 E. coli strain, known for causing intestinal infections and diarrhea, is influenced by lncRNA FUT3-AS1 .…”

Section: Lncrnas In Bacterial Zoonosesmentioning

confidence: 99%

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Xu,

He,

Yang

et al. 2024

IJMS

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Zoonoses are diseases and infections naturally transmitted between humans and vertebrate animals. They form the dominant group of diseases among emerging infectious diseases and represent critical threats to global health security. This dilemma is largely attributed to our insufficient knowledge of the pathogenesis regarding zoonotic spillover. Long non-coding RNAs (lncRNAs) are transcripts with limited coding capacity. Recent technological advancements have enabled the identification of numerous lncRNAs in humans, animals, and even pathogens. An increasing body of literature suggests that lncRNAs function as key regulators in zoonotic infection. They regulate immune-related epigenetic, transcriptional, and post-transcriptional events across a broad range of organisms. In this review, we discuss the recent research progress on the roles of lncRNAs in zoonoses. We address the classification and regulatory mechanisms of lncRNAs in the interaction between host and zoonotic pathogens. Additionally, we explore the surprising function of pathogen-derived lncRNAs in mediating the pathogenicity and life cycle of zoonotic bacteria, viruses, and parasites. Understanding how these lncRNAs influence the zoonotic pathogenesis will provide important therapeutic insights to the prevention and control of zoonoses.

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Section: Lncrnas In Bacterial Zoonosesmentioning

confidence: 99%

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Xu,

He,

Yang

et al. 2024

IJMS

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Proteomic Analysis of Thermus thermophilus Cells after Treatment with Antimicrobial Peptide

Surin,

Malykhina,

Slizen

et al. 2024

Bacteria

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In recent years, the study of antimicrobial peptides (AMPs) has garnered considerable attention due to their potential in combating antibiotic-resistant pathogens. Mass spectrometry-based proteomics provides valuable information on microbial stress responses induced by AMPs. This work aims to unravel the proteomic alterations induced by the amyloidogenic antimicrobial peptide R23I, encompassing both inhibitory and non-inhibitory concentrations. This study investigates the effects of the R23I peptide on the protein abundance of Thermus thermophilus (T. thermophilus) at different concentrations (20, 50, and 100 μg/mL). We found 82 differentially expressed proteins, including 15 upregulated and 67 downregulated proteins. We also compared the protein identification results between the PEAKS and IdentiPy programs. Our proteomic analysis revealed distinct patterns of protein expression, suggesting compensatory mechanisms in response to the R23I peptide. Notably, the alterations predominantly affected membrane and cytoplasmic proteins that play a central role in critical cellular processes such as transcription, translation, and energy conversion. This study sheds light on the complex interactions between antimicrobial peptides and bacterial responses, offering insights into microbial adaptability and potential implications for antimicrobial strategies and the understanding of microbial physiology.

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RNA-Seq analysis of long non-coding RNA in human intestinal epithelial cells infected by Shiga toxin-producing Escherichia coli

Cited by 2 publications

References 55 publications

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Proteomic Analysis of Thermus thermophilus Cells after Treatment with Antimicrobial Peptide

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