RNA Respiratory Viruses

Ison, Michael G.; Rosenberg, Eric S.

doi:10.1128/9781555815455.ch7

Cited by 3 publications

(3 citation statements)

References 204 publications

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“…40 In general, the sensitivity of antigen assays depends on where the specimen is collected (nose, throat, or lower respiratory tract-eg, tracheal aspirates, bronchoalveolar lavage), the collection method (conventional vs flocked swabs, nasopharyngeal aspirate and wash, bronchoalveolar lavage), the assay type, the virus, and the viral burden at the time of testing (the longer the time, the lower the viral load). 40,41 Viral culture is 100% specific and more sensitive than antigen assays, but it takes 2 to 3 days to run, limiting its usefulness in guiding patient management.…”

Section: Diagnostic Testsmentioning

confidence: 99%

Influenza 2010–2011: Lessons from the 2009 pandemic

Ison

Lee

2010

CCJM

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Section: Diagnostic Testsmentioning

confidence: 99%

Influenza 2010–2011: Lessons from the 2009 pandemic

Ison

Lee

2010

CCJM

Self Cite

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“…This is complicated by the fact that during most times of the year, there is cocirculation of multiple respiratory viruses. Although a range of diagnostic strategies are available, including serology, rapid antigen detection, direct fluorescent antibodies (DFA), culture and molecular diagnostics [8], olecular diagnostics are considered the gold standard for diagnosis. Molecular assays can detect multiple respiratory viruses in one assay, have enhanced sensitivity and specificity and can yield a diagnosis in a matter of minutes to hours.…”

Section: Diagnosismentioning

confidence: 99%

“…Most rapid molecular assays are limited to SARS-CoV-2, influenza and RSV and may not discriminate various sub-types of these viruses. Those that detect a wide range of pathogens are preferred and have been found consistently superior to other diagnostic methods in transplant populations but often are more complex and time consuming [8,9]. Although PCR has excellent sensitivity, poorly collected specimens can result in false-negative results.…”

Section: Diagnosismentioning

confidence: 99%

Respiratory viral infections in the immunocompromised

Ison¹

2022

Current Opinion in Pulmonary Medicine

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Purpose of reviewDuring much of the COVID-19 pandemic, respiratory viruses other than SARS-CoV-2 did not infect immunocompromised patients. As mitigation strategies lighten, there has been a rapid resurgence of respiratory viruses globally. This review will summarize our current options for the management of the common respiratory viruses in transplant recipients.Recent findingsExpansion of the availability and increased utilization of multiplex molecular assays have allowed the recognition of the scope of respiratory virus infections in the transplant populations. New antivirals for influenza, respiratory syncytial virus (RSV), parainfluenza virus (PIV) and adenovirus show promise to improve outcomes of these important infections.SummarySeveral new antiviral agents, including combination therapy of oseltamivir as well as baloxavir for influenza, fusion and nucleoprotein inhibitors for RSV, DAS181 for PIV and brincidofovir for adenovirus, hold promise to speed clearance of the virus, improve clinical outcomes and reduce the risk of resistance emergence.

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Community-acquired respiratory viruses in solid organ transplant

Nam

Ison

2019

Current Opinion in Organ Transplantation

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Purpose of reviewRespiratory viruses are common in solid organ transplant (SOT) recipients and recognized as a significant cause of mortality and morbidity. This review examines the literature on influenza and noninfluenza viruses in the SOT recipient. Recent findingsAdvances in immunosuppression and antimicrobial prophylaxis have led to improved patient and graft survival, yet respiratory viruses continue to be a common cause of disease in this population. Influenza viruses have received top priority regarding prevention and treatment, whereas advances in molecular diagnostic tests detecting an array of other respiratory viruses have expanded our knowledge about the epidemiology and impact of these viruses in both the general population and SOT patients. Effective treatment and prevention for noninfluenza respiratory viruses are only emerging. SummaryRespiratory viruses can contribute to a wide array of symptoms in SOT, particularly in lung transplant recipients. The clinical manifestations, diagnosis, and treatment options for influenza and noninfluenza viruses in SOT patients are reviewed. PCR and related molecular techniques represent the most sensitive diagnostic modalities for detection of respiratory viruses. Early therapy is associated with improved outcomes. Newer classes of antivirals and antibodies are under continuous development for many of these community acquired respiratory viruses.

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RNA Respiratory Viruses

Cited by 3 publications

References 204 publications

Influenza 2010–2011: Lessons from the 2009 pandemic

Influenza 2010–2011: Lessons from the 2009 pandemic

Respiratory viral infections in the immunocompromised

Community-acquired respiratory viruses in solid organ transplant

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