RNA replication by nuclear satellite DNA in different mouse cells

Harel, J; Hanania, Nicole; Tapiero, Haïm; Harel, L

doi:10.1016/0006-291x(68)90352-5

Cited by 44 publications

(17 citation statements)

References 8 publications

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“…2. Amphibian lampbrush chromosomes -first cytological evidence of satellite DNA transcription Biochemical evidence on the satellite DNA transcription 34 has required further cytological demonstration. Application of novel DNA/RNA-transcripts in situ hybridization (ISH) technique to the preparations of lampbrush chromosomes enabled the first cytological demonstration of satellite DNA transcription.…”

Section: Lampbrush Chromosomes Of Amphibians and Birds -A Brief Overviewmentioning

confidence: 99%

Transcription of highly repetitive tandemly organized DNA in amphibians and birds: A historical overview and modern concepts

Trofimova

Krasikova

2016

RNA Biology

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Tandemly organized highly repetitive DNA sequences are crucial structural and functional elements of eukaryotic genomes. Despite extensive evidence, satellite DNA remains an enigmatic part of the eukaryotic genome, with biological role and significance of tandem repeat transcripts remaining rather obscure. Data on tandem repeats transcription in amphibian and avian model organisms is fragmentary despite their genomes being thoroughly characterized. Review systematically covers historical and modern data on transcription of amphibian and avian satellite DNA in somatic cells and during meiosis when chromosomes acquire special lampbrush form. We highlight how transcription of tandemly repetitive DNA sequences is organized in interphase nucleus and on lampbrush chromosomes. We offer LTR-activation hypotheses of widespread satellite DNA transcription initiation during oogenesis. Recent explanations are provided for the significance of high-yield production of non-coding RNA derived from tandemly organized highly repetitive DNA. In many cases the data on the transcription of satellite DNA can be extrapolated from lampbrush chromosomes to interphase chromosomes. Lampbrush chromosomes with applied novel technical approaches such as superresolution imaging, chromosome microdissection followed by high-throughput sequencing, dynamic observation in life-like conditions provide amazing opportunities for investigation mechanisms of the satellite DNA transcription.

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Section: Lampbrush Chromosomes Of Amphibians and Birds -A Brief Overviewmentioning

confidence: 99%

Transcription of highly repetitive tandemly organized DNA in amphibians and birds: A historical overview and modern concepts

Trofimova

Krasikova

2016

RNA Biology

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“…Despite identification of satellite DNA transcription in mouse as early as the late 60s (Harel et al, 1968;Cohen et al, 1973), the structure of CT and PCT transcripts remains poorly characterized. Indeed, the repetitive nature of CT and PCT regions adds to the difficulty of their analysis.…”

Section: Where and When Are Ct And Pct Sequences Expressed?mentioning

confidence: 99%

The secret message of heterochromatin: new insights into the mechanisms and function of centromeric and pericentric repeat sequence transcription

Eymery¹,

Callanan²,

Vourc’h³

2009

Int. J. Dev. Biol.

104

114

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In the fission yeast, S. Pombe, small dsRNA generated by RNAi-dependent mechanisms are involved in the establishment and maintenance of heterochromatic regions. The existence of conserved features within the general organization of centromeric and pericentromeric repeats in yeast, mouse and human argues in favor of a conserved role for centromeric and pericentromeric-derived transcripts across these species. In support of this, evidence is accumulating that centromeric and pericentromeric sequences are transcriptionally competent in diverse biological contexts in mammalian cells. Given the importance of centromeric and pericentromeric regions, not only with respect to centromere function, but also to gene regulation, this review examines the biological contexts in which mouse and human centromeric and pericentromericspecific transcripts have been observed. The structure of the transcripts generated, the molecular mechanisms underlying their expression and their supposed functions will be discussed.

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“…However, recent evidences support the idea that the function or functions of satDNAs are not only carried out by its DNA molecule. Truly, the hypothesis of their permanent repressive status was disturbed many years ago (1960s and 1970s) when the transcription of satDNAs was firstly described (Harel et al 1968;Cohen et al 1973). Nevertheless, this fact was ignored for a long time, and only recently, with the advent of the study of ncRNAs, it was completely accepted that satDNAs are transcribed into satellite noncoding RNAs.…”

Section: Satellite Ncrnas and Their Functional Significancementioning

confidence: 97%

Satellite non-coding RNAs: the emerging players in cells, cellular pathways and cancer

et al. 2015

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For several decades, transcriptional inactivity was considered as one of the particular features of constitutive heterochromatin and, therefore, of its major component, satellite DNA sequences. However, more recently, succeeding evidences have demonstrated that these sequences can indeed be transcribed, yielding satellite non-coding RNAs with important roles in the organization and regulation of genomes. Since then, several studies have been conducted, trying to understand the function(s) of these sequences not only in the normal but also in cancer genomes. It is thought that the association between cancer and satncRNAs is mostly due to the influence of these transcripts in the genome instability, a hallmark of cancer. The few reports on satellite DNA transcription in cancer contexts point to its overexpression; however, this scenario may be far more complex, variable, and influenced by a number of factors and the exact role of satncRNAs in the oncogenic process remains poorly understood. The greater is the knowledge on the association of satncRNAs with cancer, the greater would be the opportunity to assist cancer treatment, either by the design of effective therapies targeting these molecules or by using them as biomarkers in cancer diagnosis, prognosis, and with predictive value.

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RNA replication by nuclear satellite DNA in different mouse cells

Cited by 44 publications

References 8 publications

Transcription of highly repetitive tandemly organized DNA in amphibians and birds: A historical overview and modern concepts

Transcription of highly repetitive tandemly organized DNA in amphibians and birds: A historical overview and modern concepts

The secret message of heterochromatin: new insights into the mechanisms and function of centromeric and pericentric repeat sequence transcription

Satellite non-coding RNAs: the emerging players in cells, cellular pathways and cancer

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