RNA regulators of host immunity and pathogen adaptive responses in the oral cavity

Kreth, Jens; Liu, Nan; Chen, Zhiyun; Merritt, Justin

doi:10.1016/j.micinf.2015.03.003

Cited by 7 publications

(4 citation statements)

References 127 publications

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“… 101 , 102 Another microRNA that it expression is reduced in periodontal inflammation is miR-214. 103 The expression of this miRNA increase, after activation of T cells. Through targeting phosphatase and tensin homolog (PTEN), this miRNA enhances the activity and proliferation of T cells.…”

Section: Mirnas Adaptive Immunity and Periodontal Diseasementioning

confidence: 99%

“…It seems that miR-301a by inhibiting the expression of PIAS3, which is a STAT3 activity inhibitor, can activate STAT3, which resulted in the stimulation of Th17differentiation 101,102 . Another microRNA that it expression is reduced in periodontal inflammation is miR-214 103 . The expression of this miRNA increase, after activation of T cells.…”

Section: Naïve Cd4+ T Cells Can Be Differentiated Into Effector T Cel...mentioning

confidence: 99%

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MicroRNAs and Periodontal Disease: Helpful Therapeutic Targets?

et al. 2022

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Background: Periodontal disease is the most common oral disease. This disease can be considered as an inflammatory disease. Highlight: The immune response to bacteria accumulated in the gum line plays a key role in the pathogenesis of periodontal disease. In addition to immune cells, periodontal ligament cells and gingival epithelial cells are also involved in the pathogenesis of this disease. miRNAs which are small RNA molecules with around 22 nucleotides have a considerable relationship with the immune system affecting a wide range of immunological events. These small molecules are also in relation with periodontium tissues especially periodontal ligament cells. Extensive studies have been performed in recent years on the role of miRNAs in the pathogenesis of periodontal disease. In this review paper, we have reviewed the results of these studies and discussed the role of miRNAs in the immunopathogenesis of periodontal disease comprehensively. Conclusion: miRNAs play an important role in the pathogenesis of periodontal disease and maybe helpful therapeutic targets for the treatment of periodontal disease.

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Section: Mirnas Adaptive Immunity and Periodontal Diseasementioning

confidence: 99%

Section: Naïve Cd4+ T Cells Can Be Differentiated Into Effector T Cel...mentioning

confidence: 99%

MicroRNAs and Periodontal Disease: Helpful Therapeutic Targets?

et al. 2022

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“…Although sRNAs are widely considered to act as key regulators in biofilm formation (Svenningsen, 2018), there has been limited investigation of the role of these molecules in the dynamic process of biofilm formation (Kreth, Liu, Chen, & Merritt, 2015), and it remains unknown whether sRNA exerts an important role during the process of biofilm formation in S. mutans.…”

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confidence: 99%

Small noncoding RNA sRNA0426 is involved in regulating biofilm formation in Streptococcus mutans

et al. 2020

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Evidence suggests that small noncoding RNAs (sRNAs) are involved in the complex regulatory networks governing biofilm formation. Few studies have investigated the role of sRNAs in Streptococcus mutans (S. mutans). In the present study, the association between sRNA and biofilm formation in S. mutans was explored. sRNAs that are differentially expressed in the biofilm and planktonic states of this bacterium were identified by quantitative real‐time PCR (qRT‐PCR). Confocal laser scanning microscopy was used to investigate the characteristics of biofilm formation in a standard strain of S. mutans (UA159, ATCC 700610) and ten clinical strains. Bioinformatics analyses were employed to predict and examine potential sRNA regulatory pathways. The results showed that sRNA0426 has a strong positive relationship with dynamic biofilm formation. Moreover, sRNA0426 expression was positively correlated with exopolysaccharide (EPS) production. Bioinformatics analyses showed that sRNA0426 is involved in biofilm formation such as metabolic pathways, especially carbon metabolism. Five target mRNAs (GtfB, GtfC, GtfD, ComE, and CcpA) involved in the synthesis of EPS were selected for further evaluation; the expression levels of three of these mRNAs (GtfB, GtfC, and CcpA) were positively correlated with sRNA0426 expression levels, and the expression level of one (ComE) was negatively correlated. In conclusion, the results suggested that sRNA0426 may play an important and positive role in the biofilm formation of S. mutans and provide novel insight into the S. mutans biofilm regulatory network.

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“…They illustrate how co-evolution of the oral ecosystem and host results in bacterial-fungal, bacterial-viral, and microbial-host networks that are associated with health or disease and may provide novel insights into the mechanisms of host immune responses [2]. Kreth et al examine riboregulatory RNAs and their significance for virulence and microbial persistence in the oral cavity [3]. Duran-Pinedo and Frias-Lopez discuss current paradigms of the functional role of the oral microbiome and its components in dysbiosis of oral microbial ecology and its consequence for oral and non-oral diseases [4].…”

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confidence: 99%