RNA m6A detection using raw current signals and basecalling errors from Nanopore direct RNA sequencing reads
Peng Ni,
Jinrui Xu,
Zeyu Zhong
et al.
Abstract:Motivation
Nanopore direct RNA sequencing (DRS) enables the detection of RNA N6-methyladenosine (m6A) without extra laboratory techniques. A number of supervised or comparative approaches have been developed to identify m6A from Nanopore DRS reads. However, existing methods typically utilize either statistical features of the current signals or basecalling-error features, ignoring the richer information of the raw signals of DRS reads.
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