RNA Interference against ATP as a Gene Therapy Approach for Prostate Cancer
Shuangya Chen,
Jisheng Ma,
Yunbei Xiao
et al.
Abstract:Chemotherapeutic agents targeting energy metabolism have not achieved satisfactory results in different types of tumors. Herein, we developed an RNA interference (RNAi) method against adenosine triphosphate (ATP) by constructing an interfering plasmid-expressing ATP-binding RNA aptamer, which notably inhibited the growth of prostate cancer cells through diminishing the availability of cytoplasmic ATP and impairing the homeostasis of energy metabolism, and both glycolysis and oxidative phosphorylation were supp… Show more
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