“…The RNA targets examined in our study all encode proteins previously implicated in neurodevelopmental/neurodegeneration disorders and oxidative stress response [ 44 , 46 , 54 , 55 ]. For example, mutations in TDP43 , ATXN2 , ALS2 , TAF15 , DDX3X , all of which encode RNA binding proteins, are observed in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) [ 45 , [56] , [57] , [58] ]. Mutations in PSEN1 have been correlated with loss of mitochondrial function and increased ROS production in Alzheimer's disease [ 59 ].…”